Acceleration of wound healing by composite small intestinal submucosa hydrogels through immunomodulation

• Published in: Composites. Part B, Engineering Vol. 254; p. 110550
• Main Authors: Zhang, Qing-Yi, Tan, Jie, Nie, Rong, Song, Yu-Ting, Zhou, Xing-Li, Feng, Zi-Yuan, Huang, Kai, Zou, Chen-Yu, Yuan, Qi-Juan, Zhao, Long-Mei, Zhang, Xiu-Zhen, Jiang, Yan-Lin, Liu, Li-Min, Li-Ling, Jesse, Xie, Hui-Qi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2023
• Subjects: Interleukin-10; Skin defect; Small intestinal submucosa; Tannic acid; Tannic acid; Skin defect; Interleukin-10; Small intestinal submucosa
• ISSN: 1359-8368; 1879-1069
• DOI: 10.1016/j.compositesb.2023.110550

Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since its excellent biocompatibility and bioactivities. However, the intrinsic lack of sufficient immunomodulatory activities has limited its application. Herein, tannic acid (TA) and interleukin-10 (IL-10) were supplemented to the SIS hydrogel to fabricate a novel composite hydrogel to confer an immunomodulatory activity. In addition to the improvement in swelling and anti-degradation properties, the composite SIS hydrogel has attained satisfying free radical scavenging and sustained IL-10 release. Meanwhile, the hydrogel possessed excellent anti-oxidative and immunomodulatory abilities to promote the polarization of M2c macrophages, thereby regulating collagen synthesis and providing a favorable immune environment for angiogenesis and extracellular matrix remodeling. Above results have therefore provided a facile but effective strategy to improve the therapeutic effects of the SIS hydrogel and expand its scope of clinical applications. The composite SIS hydrogel possessed excellent anti-oxidative and immunomodulatory capacities to promote the polarization of M2c macrophages, thereby regulate collagen synthesis and provide a favorable immune environment for angiogenesis and extracellular matrix remodeling. Through these functions, the composite SIS hydrogel could effectively facilitate wound healing and attenuate scar hyperplasia. [Display omitted]