LC–MS/MS Determination of Ginsenoside Compound K and its Metabolite 20( S )-Protopanaxadiol in Human Plasma and Urine: Applications in a Clinical Study

Ginsenoside compound K (CK) is considered to be a potential therapeutic drug for rheumatoid arthritis because of its good anti-inflammatory activity. The purpose of this work was to establish a rapid, sensitive and specific method for determination of CK and its active metabolite 20(S)-protopanaxadi...

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Published inBioanalysis Vol. 11; no. 5; pp. 365 - 380
Main Authors Yang, Li, Wang, Chun-Yang, Xie, Xiao-Nv, Wang, Yi-Cheng, Peng, Jing-Bo, Huang, Wei-Hua, Chen, Yao, Ouyang, Dong-Sheng, Tan, Zhi-Rong
Format Journal Article
LanguageEnglish
Published England Newlands Press 01.03.2019
Subjects
Acids
Anti-inflammatory agents
Arthritis, Rheumatoid
Biological products
Chromatography
Chromatography, Liquid - methods
Female
Ginsenosides
Ginsenosides - pharmacology
Ginsenosides - therapeutic use
Humans
Inflammation
Ions
Male
Mass spectrometry
Mass spectroscopy
Metabolites
Microorganisms
Panax - chemistry
Pharmaceuticals
Plasma
Rheumatoid arthritis
Sapogenins - pharmacology
Sapogenins - therapeutic use
Scientific imaging
Studies
Tandem Mass Spectrometry - methods
Urine
Beijing China
United States > US
China
Germany
ginsenoside compound K
pharmacokinetics
LC–MS/MS
20-protopanaxadiol
Online AccessGet full text
ISSN1757-6180
1757-6199
DOI10.4155/bio-2018-0185

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Abstract Ginsenoside compound K (CK) is considered to be a potential therapeutic drug for rheumatoid arthritis because of its good anti-inflammatory activity. The purpose of this work was to establish a rapid, sensitive and specific method for determination of CK and its active metabolite 20(S)-protopanaxadiol (20(S)-PPD). Materials & methods: The analytes and internal standards were extracted by liquid-liquid extraction. Then, were separated by high performance liquid phase and determined by triple quadrupole mass spectrometry. A LC-MS/MS using liquid-liquid extraction was developed for determining CK over the concentration range 1.00-1002.00 ng/ml and 0.15-54.30 ng/ml for 20(S)-PPD. The lower limits of quantification for CK and 20(S)-PPD were 1.00 and 0.15 ng/ml, respectively. This method was successfully validated for detecting both CK and 20(S)-PPD in the human plasma and urine, and was proved to be suitable for the pharmacokinetic study of CK in healthy Chinese volunteers. ChiCTR-TRC-14004824.
AbstractList Aim: Ginsenoside compound K (CK) is considered to be a potential therapeutic drug for rheumatoid arthritis because of its good anti-inflammatory activity. The purpose of this work was to establish a rapid, sensitive and specific method for determination of CK and its active metabolite 20(S)-protopanaxadiol (20(S)-PPD). Materials & methods: The analytes and internal standards were extracted by liquid–liquid extraction. Then, were separated by high performance liquid phase and determined by triple quadrupole mass spectrometry. Results: A LC–MS/MS using liquid–liquid extraction was developed for determining CK over the concentration range 1.00–1002.00 ng/ml and 0.15–54.30 ng/ml for 20(S)-PPD. The lower limits of quantification for CK and 20(S)-PPD were 1.00 and 0.15 ng/ml, respectively. Conclusion: This method was successfully validated for detecting both CK and 20(S)-PPD in the human plasma and urine, and was proved to be suitable for the pharmacokinetic study of CK in healthy Chinese volunteers. Clinical trial registration number: ChiCTR-TRC-14004824.
Ginsenoside compound K (CK) is considered to be a potential therapeutic drug for rheumatoid arthritis because of its good anti-inflammatory activity. The purpose of this work was to establish a rapid, sensitive and specific method for determination of CK and its active metabolite 20(S)-protopanaxadiol (20(S)-PPD). Materials & methods: The analytes and internal standards were extracted by liquid-liquid extraction. Then, were separated by high performance liquid phase and determined by triple quadrupole mass spectrometry. A LC-MS/MS using liquid-liquid extraction was developed for determining CK over the concentration range 1.00-1002.00 ng/ml and 0.15-54.30 ng/ml for 20(S)-PPD. The lower limits of quantification for CK and 20(S)-PPD were 1.00 and 0.15 ng/ml, respectively. This method was successfully validated for detecting both CK and 20(S)-PPD in the human plasma and urine, and was proved to be suitable for the pharmacokinetic study of CK in healthy Chinese volunteers. ChiCTR-TRC-14004824.
Author Huang, Wei-Hua
Tan, Zhi-Rong
Xie, Xiao-Nv
Ouyang, Dong-Sheng
Yang, Li
Peng, Jing-Bo
Wang, Chun-Yang
Chen, Yao
Wang, Yi-Cheng
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  givenname: Wei-Hua
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  givenname: Yao
  surname: Chen
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  givenname: Dong-Sheng
  surname: Ouyang
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  organization: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha410008, PR China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha410078, PR China
– sequence: 9
  givenname: Zhi-Rong
  surname: Tan
  fullname: Tan, Zhi-Rong
  organization: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha410008, PR China, Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha41007, PR China, National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha410008, Hunan, PR China
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Keywords ginsenoside compound K
pharmacokinetics
LC–MS/MS
20-protopanaxadiol
Language English
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Snippet Ginsenoside compound K (CK) is considered to be a potential therapeutic drug for rheumatoid arthritis because of its good anti-inflammatory activity. The...
Aim: Ginsenoside compound K (CK) is considered to be a potential therapeutic drug for rheumatoid arthritis because of its good anti-inflammatory activity. The...
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StartPage 365
SubjectTerms Acids
Anti-inflammatory agents
Arthritis, Rheumatoid
Biological products
Chromatography
Chromatography, Liquid - methods
Female
Ginsenosides
Ginsenosides - pharmacology
Ginsenosides - therapeutic use
Humans
Inflammation
Ions
Male
Mass spectrometry
Mass spectroscopy
Metabolites
Microorganisms
Panax - chemistry
Pharmaceuticals
Plasma
Rheumatoid arthritis
Sapogenins - pharmacology
Sapogenins - therapeutic use
Scientific imaging
Studies
Tandem Mass Spectrometry - methods
Urine
Title LC–MS/MS Determination of Ginsenoside Compound K and its Metabolite 20( S )-Protopanaxadiol in Human Plasma and Urine: Applications in a Clinical Study
URI https://www.ncbi.nlm.nih.gov/pubmed/30873858
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