Intermolecular Interaction Between BODIPY and TPE Enhances Phototherapy

• Published in: Advanced optical materials Vol. 12; no. 15
• Main Authors: Gong, Zhichao, Kang, Guangbo, Shi, Ruijie, Jiang, Xu, Rong, Xuejiao, Du, Xiaobing, Wu, Jiang, Huang, He, Meng, Shuxian
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.05.2024
• Subjects: Biocompatibility; bodipy&tpe; Core-shell structure; Economic impact; Encapsulation; flexible regulation; intermolecular interaction; Nanoparticles; non‐synthesis; Optical materials; Optical properties; synergistic therapeutic properties
• ISSN: 2195-1071; 2195-1071
• DOI: 10.1002/adom.202303033

Fluoroborodipyrrole (BODIPY) and Tetraphenylethylene (TPE) are well‐known molecules in the realm of optical materials, celebrated for their exceptional properties. Recent research increasingly focuses on their combined use. In this study, a novel non‐synthetic method is taken to harness the synergistic therapeutic potential stemming from intermolecular interactions by employing nanoparticle encapsulation and core–shell structure. In vitro and in vivo experiments results show that the nanoparticles  encapsulating BODIPY and TPE exhibit low cytotoxicity, efficient antitumor properties, and excellent visualization, achieving remarkable 1+1>2 effects. This innovative method not only provides high therapeutic efficacy, but also reduces time and economic costs, providing a novel perspective for exploring the combination of BODIPY and TPE as well as similar molecules in the field of optical materials. Herein, a novel non‐synthetic method to combine BODIPY and TPE by employing nanoparticle encapsulation and core–shell structure, resulting the remarkable synergy effects of phototherapy is reported. This strategy provides a novel perspective for researches on the combined utilization of different molecules in the fields of phototherapy, optoelectronic materials, fluorescent probes, and so on.