Synthesis of 2‐Quinolones based on Visible Light‐Catalyzed Annulation of Diazo compounds

Herein, we report a photocatalytic method for the synthesis of 2‐quinolones under mild conditions by employing α‐diazo acetamide as substrates. The use of Eosin Y as a photocatalyst allows an economical and environmentally benign synthetic method. The process involves the generation of radicals from...

Full description

Saved in:
Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 366; no. 8; pp. 1827 - 1832
Main Authors Bae, Jaehee, Chae, Jiyoung, Park, Cheol‐Min
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 23.04.2024
Wiley Subscription Services, Inc
Subjects
Chemical reactions
Chemistry
Chemistry, Applied
Chemistry, Organic
Diazo compounds
Electron transfer
PCET
Photocatalysis
Physical Sciences
Quinolones
Radical reactions
Science & Technology
Substrates
Synthesis
Diazo compounds
QUINOLIN-2(1H)-ONES
Radical reactions
Photocatalysis
3-COMPONENT REACTION
STRATEGY
PCET
EOSIN Y
DERIVATIVES
Quinolones
Online AccessGet full text
ISSN1615-4150
1615-4169
DOI10.1002/adsc.202301220

Cover

More Information
Summary:Herein, we report a photocatalytic method for the synthesis of 2‐quinolones under mild conditions by employing α‐diazo acetamide as substrates. The use of Eosin Y as a photocatalyst allows an economical and environmentally benign synthetic method. The process involves the generation of radicals from diazo compounds promoted by a visible‐light‐induced proton‐coupled electron transfer (PCET) mechanism. The method demonstrates a broad substrate scope to provide various aryl‐ and alkyl‐substituted 2‐quinolones. To support the proposed mechanism, a series of mechanistic experiments were conducted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202301220