A covalent organic framework-based nanoreactor for enhanced photothermal therapy via inhibiting intracellular heat defense systems

Herein, we report an indocyanine green (ICG)-decorated and glucose oxidase (GOx)-loaded nanoscale composite COF material via a stepwise post-synthetic modification. The obtained GOx@COF-ICG can achieve synergistic inhibition of intracellular heat defense systems through starvation therapy to enhance...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 48; pp. 7463 - 7466
Main Authors Li, Yan-An, Wan, Jing-Jing, Li, Wen-Yan, Guan, Qun, Dong, Yu-Bin
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 13.06.2023
Subjects
Animals
Cell Line, Tumor
Cell Survival
Glucose oxidase
Heat-Shock Response
Humans
Intracellular Space - chemistry
Metal-Organic Frameworks - chemistry
Nanostructures
Neoplasms - therapy
Photothermal Therapy
Therapy
Online AccessGet full text
ISSN1359-7345
1364-548X
1364-548X
DOI10.1039/D3CC01153D

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Summary:Herein, we report an indocyanine green (ICG)-decorated and glucose oxidase (GOx)-loaded nanoscale composite COF material via a stepwise post-synthetic modification. The obtained GOx@COF-ICG can achieve synergistic inhibition of intracellular heat defense systems through starvation therapy to enhance photothermal therapy of tumors.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/D3CC01153D