Enhanced bone formation in lipodystrophic PPARγhyp/hyp mice relocates haematopoiesis to the spleen
The peroxisome proliferator‐activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARγ in fat of lipodystrophic PPARγ hyp/hyp mice, strongly...
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| Published in | EMBO reports Vol. 5; no. 10; pp. 1007 - 1012 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.10.2004
Nature Publishing Group UK |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1469-221X 1469-3178 |
| DOI | 10.1038/sj.embor.7400254 |
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| Abstract | The peroxisome proliferator‐activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARγ in fat of lipodystrophic PPARγ
hyp/hyp
mice, strongly enhanced bone mass and consequentially reduced the bone‐marrow cavity. Consistent with this, PPARγ
hyp/hyp
mice had a significant decrease in bone marrow cellularity and resorted to extramedullary haematopoiesis in the spleen to maintain haematopoiesis. Our data indicate that antagonizing PPARγ activity in fat could be an effective way to combat osteoporosis and suggest that haematopoietic function should be scrutinized in lipodystrophic subjects. |
|---|---|
| AbstractList | The peroxisome proliferator‐activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARγ in fat of lipodystrophic PPARγhyp/hyp mice, strongly enhanced bone mass and consequentially reduced the bone‐marrow cavity. Consistent with this, PPARγhyp/hyp mice had a significant decrease in bone marrow cellularity and resorted to extramedullary haematopoiesis in the spleen to maintain haematopoiesis. Our data indicate that antagonizing PPARγ activity in fat could be an effective way to combat osteoporosis and suggest that haematopoietic function should be scrutinized in lipodystrophic subjects. The peroxisome proliferator-activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARγ in fat of lipodystrophic PPARγ hyp/hyp mice, strongly enhanced bone mass and consequentially reduced the bone-marrow cavity. Consistent with this, PPARγ hyp/hyp mice had a significant decrease in bone marrow cellularity and resorted to extramedullary haematopoiesis in the spleen to maintain haematopoiesis. Our data indicate that antagonizing PPARγ activity in fat could be an effective way to combat osteoporosis and suggest that haematopoietic function should be scrutinized in lipodystrophic subjects. |
| Author | Back, Jonathan Cock, Terrie‐Anne Kastner, Philippe Elefteriou, Florent Karsenty, Gérard Auwerx, Johan Chan, Susan |
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| Cites_doi | 10.1016/S0092-8674(00)81558-5 10.1126/science.1090985 10.1101/gad.12.20.3168 10.1097/00003072-199501000-00021 10.1038/sj.embor.7400082 10.1002/ajmg.10437 10.1073/pnas.2336090100 10.1006/bbrc.1999.0896 10.1016/S0092-8674(02)01049-8 10.1182/blood.V89.5.1507 10.1210/en.2003-0746 10.1073/pnas.0308744101 10.1182/blood.V95.11.3363 10.1056/NEJM199502023320506 10.1038/nature02040 10.1038/nature01660 10.1002/ajh.2830110307 10.1172/JCI200419900 10.1182/blood-2003-11-4089 10.1093/hmg/7.3.435 10.1146/annurev.nutr.22.010402.102808 10.1210/endo.143.6.8834 10.1097/00005792-200303000-00007 10.1016/S0301-472X(02)00899-8 10.1016/S8756-3282(00)00317-3 10.1172/JCI0214506 10.1101/gad.12.20.3182 10.1002/(SICI)1097-4644(19990901)74:3<357::AID-JCB5>3.0.CO;2-7 10.1038/nature02041 10.1016/S0960-9822(02)70684-2 |
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| Keywords | nuclear receptors extramedullary haematopoiesis osteoporosis lipodystrophy |
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| References | Bennett BDet al (1996) A role for leptin and its cognate receptor in hematopoiesis. Curr Biol6: 1170-1180 Tagaya Het al (2000) Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood95: 3363-3370 Klein RFet al (2004) Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science303: 229-232 Back Jet al (2004) PU.1 determines the self-renewal capacity of erythroid progenitor cells. Blood103: 3615-3623 Ogawa Set al (1999) Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene: PPARγ expression in osteoblasts. Biochem Biophys Res Commun260: 122-126 Lecka-Czernik B, Gubrij I, Moerman EJ, Kajkenova O, Lipschitz DA, Manolagas SC, Jilka RL (1999) Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2. J Cell Biochem74: 357-371 Okubo K, Yanai N, Ikawa S, Obinata M (2002) Reversible switching of expression of c-kit and Pqx-5 in immature hematopoietic progenitor cells by stromal cells. Exp Hematol30: 1193-1201 Nuttall ME, Gimble JM (2000) Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?Bone27: 177-184 Ducy Pet al (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell100: 197-207 Koutnikova Het al (2003) Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice. Proc Natl Acad Sci USA100: 14457-14462 Rajab Aet al (2002) Heterogeneity for congenital generalized lipodystrophy in seventeen patients from Oman. Am J Med Genet110: 219-225 Mikhail AAet al (1997) Leptin stimulates fetal and adult erythroid and myeloid development. Blood89: 1507-1512 Picard F, Auwerx J (2002) PPARγ and glucose homeostasis. Annu Rev Nutr22: 167-197 Calvi LMAet al (2003) Osteoblastic cells regulate the hematopoietic stem cell niche. Nature425: 841-847 Misra A, Garg A (2003) Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. Medicine (Baltimore)82: 129-146 Zhang JNet al (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature425: 836-841 Takeda Set al (2002) Leptin regulates bone formation via the sympathetic nervous system. Cell111: 305-317 Meirhaeghe Aet al (1998) A genetic polymorphism of the PPARγ gene influences plasma leptin levels in obese humans. Hum Mol Genet7: 435-440 Cock TAet al (2004) PPARγ: too much of a good thing causes harm. EMBO Rep5: 142-147 Shimomura Iet al (1998) Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev12: 3182-3194 Yokota Tet al (2002) Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest109: 1303-1310 Manolagas SC, Jilka RL (1995) Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med332: 305-311 Lecka-Czernik Bet al (2002) Divergent effects of selective PPARγ2 ligands on adipocyte versus osteoblast differentiation. Endocrinology143: 2376-2384 Rzonca SOet al (2004) Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology145: 401-406 Harada S, Rodan GA (2003) Control of osteoblast function and regulation of bone mass. Nature423: 349-355 Freedman MH, Saunders EF (1981) Hematopoiesis in the human spleen. Am J Hematol11: 271-275 Akune Tet al (2004) PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest113: 846-855 Caluser C, Scott A, Macapinlac H, Yeh S, Rosenfelt N, Farid B, Abdel-Dayem HM, Larson SM, Kalaigian H (1995) Extramedullary hematopoiesis assessment in a patient with osteopetrosis. Clin Nucl Med20: 75 Elefteriou Fet al (2004) Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA101: 3258-3263 Moitra Jet al (1998) Life without fat: a transgenic mouse. Genes Dev12: 3168-3181 2004; 101 2004; 145 2004; 303 2004; 103 2000; 27 2002; 30 2002; 110 2002; 111 1997; 89 2000; 95 2004; 5 1995; 332 1995; 20 2003; 425 2004; 113 2002; 143 1999; 260 2002; 22 1999; 74 2000; 100 2002; 109 2003; 423 1998; 7 2003; 82 2003; 100 1998; 12 1996; 6 1981; 11 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – reference: Calvi LMAet al (2003) Osteoblastic cells regulate the hematopoietic stem cell niche. Nature425: 841-847 – reference: Lecka-Czernik Bet al (2002) Divergent effects of selective PPARγ2 ligands on adipocyte versus osteoblast differentiation. Endocrinology143: 2376-2384 – reference: Okubo K, Yanai N, Ikawa S, Obinata M (2002) Reversible switching of expression of c-kit and Pqx-5 in immature hematopoietic progenitor cells by stromal cells. Exp Hematol30: 1193-1201 – reference: Picard F, Auwerx J (2002) PPARγ and glucose homeostasis. Annu Rev Nutr22: 167-197 – reference: Ogawa Set al (1999) Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene: PPARγ expression in osteoblasts. Biochem Biophys Res Commun260: 122-126 – reference: Meirhaeghe Aet al (1998) A genetic polymorphism of the PPARγ gene influences plasma leptin levels in obese humans. Hum Mol Genet7: 435-440 – reference: Akune Tet al (2004) PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest113: 846-855 – reference: Rzonca SOet al (2004) Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology145: 401-406 – reference: Misra A, Garg A (2003) Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. Medicine (Baltimore)82: 129-146 – reference: Manolagas SC, Jilka RL (1995) Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med332: 305-311 – reference: Koutnikova Het al (2003) Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice. Proc Natl Acad Sci USA100: 14457-14462 – reference: Takeda Set al (2002) Leptin regulates bone formation via the sympathetic nervous system. Cell111: 305-317 – reference: Back Jet al (2004) PU.1 determines the self-renewal capacity of erythroid progenitor cells. Blood103: 3615-3623 – reference: Lecka-Czernik B, Gubrij I, Moerman EJ, Kajkenova O, Lipschitz DA, Manolagas SC, Jilka RL (1999) Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2. J Cell Biochem74: 357-371 – reference: Moitra Jet al (1998) Life without fat: a transgenic mouse. Genes Dev12: 3168-3181 – reference: Tagaya Het al (2000) Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood95: 3363-3370 – reference: Cock TAet al (2004) PPARγ: too much of a good thing causes harm. EMBO Rep5: 142-147 – reference: Harada S, Rodan GA (2003) Control of osteoblast function and regulation of bone mass. Nature423: 349-355 – reference: Nuttall ME, Gimble JM (2000) Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?Bone27: 177-184 – reference: Rajab Aet al (2002) Heterogeneity for congenital generalized lipodystrophy in seventeen patients from Oman. Am J Med Genet110: 219-225 – reference: Caluser C, Scott A, Macapinlac H, Yeh S, Rosenfelt N, Farid B, Abdel-Dayem HM, Larson SM, Kalaigian H (1995) Extramedullary hematopoiesis assessment in a patient with osteopetrosis. Clin Nucl Med20: 75 – reference: Mikhail AAet al (1997) Leptin stimulates fetal and adult erythroid and myeloid development. Blood89: 1507-1512 – reference: Zhang JNet al (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature425: 836-841 – reference: Freedman MH, Saunders EF (1981) Hematopoiesis in the human spleen. Am J Hematol11: 271-275 – reference: Yokota Tet al (2002) Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest109: 1303-1310 – reference: Bennett BDet al (1996) A role for leptin and its cognate receptor in hematopoiesis. Curr Biol6: 1170-1180 – reference: Ducy Pet al (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell100: 197-207 – reference: Elefteriou Fet al (2004) Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA101: 3258-3263 – reference: Shimomura Iet al (1998) Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev12: 3182-3194 – reference: Klein RFet al (2004) Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science303: 229-232 – volume: 89 start-page: 1507 year: 1997 end-page: 1512 article-title: Leptin stimulates fetal and adult erythroid and myeloid development publication-title: Blood – volume: 145 start-page: 401 year: 2004 end-page: 406 article-title: Bone is a target for the antidiabetic compound rosiglitazone publication-title: Endocrinology – volume: 425 start-page: 841 year: 2003 end-page: 847 article-title: Osteoblastic cells regulate the hematopoietic stem cell niche publication-title: Nature – volume: 6 start-page: 1170 year: 1996 end-page: 1180 article-title: A role for leptin and its cognate receptor in hematopoiesis publication-title: Curr Biol – volume: 303 start-page: 229 year: 2004 end-page: 232 article-title: Regulation of bone mass in mice by the lipoxygenase gene Alox15 publication-title: Science – volume: 82 start-page: 129 year: 2003 end-page: 146 article-title: Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature publication-title: Medicine (Baltimore) – volume: 103 start-page: 3615 year: 2004 end-page: 3623 article-title: PU.1 determines the self‐renewal capacity of erythroid progenitor cells publication-title: Blood – volume: 30 start-page: 1193 year: 2002 end-page: 1201 article-title: Reversible switching of expression of c‐kit and Pqx‐5 in immature hematopoietic progenitor cells by stromal cells publication-title: Exp Hematol – volume: 100 start-page: 14457 year: 2003 end-page: 14462 article-title: Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice publication-title: Proc Natl Acad Sci USA – volume: 20 start-page: 75 year: 1995 article-title: Extramedullary hematopoiesis assessment in a patient with osteopetrosis publication-title: Clin Nucl Med – volume: 100 start-page: 197 year: 2000 end-page: 207 article-title: Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass publication-title: Cell – volume: 260 start-page: 122 year: 1999 end-page: 126 article-title: Association of bone mineral density with a polymorphism of the peroxisome proliferator‐activated receptor gamma gene: PPARγ expression in osteoblasts publication-title: Biochem Biophys Res Commun – volume: 111 start-page: 305 year: 2002 end-page: 317 article-title: Leptin regulates bone formation via the sympathetic nervous system publication-title: Cell – volume: 7 start-page: 435 year: 1998 end-page: 440 article-title: A genetic polymorphism of the PPARγ gene influences plasma leptin levels in obese humans publication-title: Hum Mol Genet – volume: 113 start-page: 846 year: 2004 end-page: 855 article-title: PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors publication-title: J Clin Invest – volume: 27 start-page: 177 year: 2000 end-page: 184 article-title: Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? publication-title: Bone – volume: 5 start-page: 142 year: 2004 end-page: 147 article-title: PPARγ: too much of a good thing causes harm publication-title: EMBO Rep – volume: 143 start-page: 2376 year: 2002 end-page: 2384 article-title: Divergent effects of selective PPARγ2 ligands on adipocyte versus osteoblast differentiation publication-title: Endocrinology – volume: 101 start-page: 3258 year: 2004 end-page: 3263 article-title: Serum leptin level is a regulator of bone mass publication-title: Proc Natl Acad Sci USA – volume: 12 start-page: 3168 year: 1998 end-page: 3181 article-title: Life without fat: a transgenic mouse publication-title: Genes Dev – volume: 12 start-page: 3182 year: 1998 end-page: 3194 article-title: Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP‐1c in adipose tissue: model for congenital generalized lipodystrophy publication-title: Genes Dev – volume: 11 start-page: 271 year: 1981 end-page: 275 article-title: Hematopoiesis in the human spleen publication-title: Am J Hematol – volume: 22 start-page: 167 year: 2002 end-page: 197 article-title: PPARγ and glucose homeostasis publication-title: Annu Rev Nutr – volume: 425 start-page: 836 year: 2003 end-page: 841 article-title: Identification of the haematopoietic stem cell niche and control of the niche size publication-title: Nature – volume: 109 start-page: 1303 year: 2002 end-page: 1310 article-title: Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins publication-title: J Clin Invest – volume: 423 start-page: 349 year: 2003 end-page: 355 article-title: Control of osteoblast function and regulation of bone mass publication-title: Nature – volume: 74 start-page: 357 year: 1999 end-page: 371 article-title: Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2 publication-title: J Cell Biochem – volume: 95 start-page: 3363 year: 2000 end-page: 3370 article-title: Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice publication-title: Blood – volume: 332 start-page: 305 year: 1995 end-page: 311 article-title: Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis publication-title: N Engl J Med – volume: 110 start-page: 219 year: 2002 end-page: 225 article-title: Heterogeneity for congenital generalized lipodystrophy in seventeen patients from Oman publication-title: Am J Med Genet – ident: e_1_2_6_8_1 doi: 10.1016/S0092-8674(00)81558-5 – ident: e_1_2_6_12_1 doi: 10.1126/science.1090985 – ident: e_1_2_6_20_1 doi: 10.1101/gad.12.20.3168 – ident: e_1_2_6_5_1 doi: 10.1097/00003072-199501000-00021 – ident: e_1_2_6_7_1 doi: 10.1038/sj.embor.7400082 – ident: e_1_2_6_25_1 doi: 10.1002/ajmg.10437 – ident: e_1_2_6_13_1 doi: 10.1073/pnas.2336090100 – ident: e_1_2_6_22_1 doi: 10.1006/bbrc.1999.0896 – ident: e_1_2_6_29_1 doi: 10.1016/S0092-8674(02)01049-8 – ident: e_1_2_6_18_1 doi: 10.1182/blood.V89.5.1507 – ident: e_1_2_6_26_1 doi: 10.1210/en.2003-0746 – ident: e_1_2_6_9_1 doi: 10.1073/pnas.0308744101 – ident: e_1_2_6_28_1 doi: 10.1182/blood.V95.11.3363 – ident: e_1_2_6_16_1 doi: 10.1056/NEJM199502023320506 – ident: e_1_2_6_6_1 doi: 10.1038/nature02040 – ident: e_1_2_6_11_1 doi: 10.1038/nature01660 – ident: e_1_2_6_10_1 doi: 10.1002/ajh.2830110307 – ident: e_1_2_6_2_1 doi: 10.1172/JCI200419900 – ident: e_1_2_6_3_1 doi: 10.1182/blood-2003-11-4089 – ident: e_1_2_6_17_1 doi: 10.1093/hmg/7.3.435 – ident: e_1_2_6_24_1 doi: 10.1146/annurev.nutr.22.010402.102808 – ident: e_1_2_6_15_1 doi: 10.1210/endo.143.6.8834 – ident: e_1_2_6_19_1 doi: 10.1097/00005792-200303000-00007 – ident: e_1_2_6_23_1 doi: 10.1016/S0301-472X(02)00899-8 – ident: e_1_2_6_21_1 doi: 10.1016/S8756-3282(00)00317-3 – ident: e_1_2_6_30_1 doi: 10.1172/JCI0214506 – ident: e_1_2_6_27_1 doi: 10.1101/gad.12.20.3182 – ident: e_1_2_6_14_1 doi: 10.1002/(SICI)1097-4644(19990901)74:3<357::AID-JCB5>3.0.CO;2-7 – ident: e_1_2_6_31_1 doi: 10.1038/nature02041 – ident: e_1_2_6_4_1 doi: 10.1016/S0960-9822(02)70684-2 |
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| Snippet | The peroxisome proliferator‐activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has... The peroxisome proliferator-activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has... |
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| SubjectTerms | extramedullary haematopoiesis lipodystrophy nuclear receptors osteoporosis Scientific Report |
| Title | Enhanced bone formation in lipodystrophic PPARγhyp/hyp mice relocates haematopoiesis to the spleen |
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