Enhanced bone formation in lipodystrophic PPARγhyp/hyp mice relocates haematopoiesis to the spleen

• Published in: EMBO reports Vol. 5; no. 10; pp. 1007 - 1012
• Main Authors: Cock, Terrie-Anne, Back, Jonathan, Elefteriou, Florent, Karsenty, Gérard, Kastner, Philippe, Chan, Susan, Auwerx, Johan
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2004; Nature Publishing Group UK
• Subjects: extramedullary haematopoiesis; lipodystrophy; nuclear receptors; osteoporosis; Scientific Report; nuclear receptors; extramedullary haematopoiesis; osteoporosis; lipodystrophy
• ISSN: 1469-221X; 1469-3178
• DOI: 10.1038/sj.embor.7400254

The peroxisome proliferator‐activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARγ in fat of lipodystrophic PPARγ hyp/hyp mice, strongly enhanced bone mass and consequentially reduced the bone‐marrow cavity. Consistent with this, PPARγ hyp/hyp mice had a significant decrease in bone marrow cellularity and resorted to extramedullary haematopoiesis in the spleen to maintain haematopoiesis. Our data indicate that antagonizing PPARγ activity in fat could be an effective way to combat osteoporosis and suggest that haematopoietic function should be scrutinized in lipodystrophic subjects.