Synthesis, spectral, thermal and antimicrobial studies on cobalt(II), nickel(II), copper(II), zinc(II) and palladium(II) complexes containing thiosemicarbazone ligand

• Published in: Journal of molecular structure Vol. 1157; pp. 381 - 394
• Main Authors: El-Sawaf, Ayman K., El-Essawy, Farag, Nassar, Amal A., El-Samanody, El-Sayed A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.04.2018
• Subjects: Antimicrobial activity; Complexation; N4-morpholinyl isatin-3-thiosemicarbazone; Spectroscopic methods; Thermal study; Spectroscopic methods; Complexation; Antimicrobial activity; N4-morpholinyl isatin-3-thiosemicarbazone; Thermal study
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2017.12.075

The coordination characteristic of new N4-morpholinyl isatin-3-thiosemicarbazone (HL) towards Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) has been studies. The structures of the complexes were described by elemental analyses, molar conductivity, magnetic, thermal and spectral (IR, UV–Vis, 1H and 13C NMR and ESR) studies. On the basis of analytical and spectral studies the ligand behaves as monobasic tridentate ONS donor forming two five membered rings towards cobalt, copper and palladium and afforded complexes of the kind [M(L)X], (MCo, Cu or Pd; XCl, Br or OAc). Whereas the ligand bound to NiCl2 as neutral tridentate ONS donor and with ZnCl2 as neutral bidentate NS donor. The newly synthesized thiosemicarbazone ligand and some of its complexes were examined for antimicrobial activity against 2 gram negative bacterial strains (Escherichia coli Pseudomonas and aeruginosa), 2 gram positive bacterial strains (Streptococcus pneumoniae and Staphylococcus aureus)} and two Pathogenic fungi (Aspergillus fumigatus and Candida albicans). All metal complexes possess higher antimicrobial activity comparing with the free thiosemicarbazone ligand. The high potent activities of the complexes may arise from the coordination and chelation, which tends to make metal complexes act as more controlling and potent antimicrobial agents, thus hindering the growing of the microorganisms. The antimicrobial results also show that copper bromide complex is better antimicrobial agent as compared to the Schiff base and its metal complexes. [Display omitted] •A new thiosemicarbazone ligand and some of its transition metal(II) complexes were synthesized.•The title compounds were characterized using spectroscopic methods.•In most complexes the ligand acts a monobasic tridentate ONS donor forming two five membered rings.•The complexation led to a remarkable increase in antimicrobial activity.