Adsorption of doxorubicin hydrochloride onto thermally treated green adsorbent: Equilibrium, kinetic and thermodynamic studies

•Synthesis and Characterization of MSAC.•Studies adsorption of Doxorubicin Hydrochloride at MSAC.•Studying the mechanism of adsorption and rate controlling steps.•Statistical and physical simulation. The mango seeds activated carbon (MSAC) nanoparticles were created because these materials have high...

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Published inJournal of molecular structure Vol. 1263; p. 133160
Main Authors Altalhi, Tariq A., Ibrahim, Mohamed M., Mersal, Gaber A.M., Mahmoud, M.H.H., Kumeria, Tushar, El-Desouky, Mohamed G., El-Bindary, Ashraf A., El-Bindary, Mohamed A.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 05.09.2022
Subjects
Adsorption isotherm
Adsorption kinetics
Doxorubicin hydrochloride
MSAC
Thermodynamics
Thermodynamics
Adsorption kinetics
Doxorubicin hydrochloride
MSAC
Adsorption isotherm
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ISSN0022-2860
1872-8014
DOI10.1016/j.molstruc.2022.133160

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Summary:•Synthesis and Characterization of MSAC.•Studies adsorption of Doxorubicin Hydrochloride at MSAC.•Studying the mechanism of adsorption and rate controlling steps.•Statistical and physical simulation. The mango seeds activated carbon (MSAC) nanoparticles were created because these materials have high biocompatibility and might be used as a medication carrier. The anti-cancer medication doxorubicin hydrochloride (DOX) was loaded on MSAC nanoparticles in this study was characterized by the XRD, SEM, and BET showed that the surface area being 443 m2/g while pore volume was 0.649 cm3/g. The doxorubicin technique was applied performance factors, contact period, pH, concentration, adsorbent dose, and temperature were all examined to evaluate DOX adsorption. Greatest DOX adsorption on MSAC found to be at a pH of 5. This shows that, because to the outstanding components employed in the MSAC structure, the existing difficulty of employing larger doses of doxorubicin could be effectively mitigated. The created approach significantly enhanced DOX adsorption, indicating that the produced nanocomposite might be used to deliver drugs. The adsorption process of MSAC was at its optimum of 0.25 mmol/g, and the adsorption isotherm fit to the Langmuir model, while fitted to pseudo-second-order model for adsorption kinetics. DOX adsorption on MSAC is endothermic and spontaneous, according to thermodynamic studies.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2022.133160