Dietary fructose as a metabolic risk factor

• Published in: American Journal of Physiology: Cell Physiology Vol. 323; no. 3; pp. C847 - C856
• Main Authors: Sindhunata, Daniko P., Meijnikman, A. Stijn, Gerdes, Victor E. A., Nieuwdorp, Max
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.09.2022
• Subjects: Dietary intake; Disease resistance; Fatty liver; Fructose; Insulin; Insulin resistance; Intestinal microflora; Intestine; Lipid metabolism; Liver diseases; Metabolic disorders; Microbiota; Phenotypes; Risk factors; Transplantation
• ISSN: 0363-6143; 1522-1563; 1522-1563
• DOI: 10.1152/ajpcell.00439.2021

Over the past decades, the role of the intestinal microbiota in metabolic diseases has come forward. In this regard, both composition and function of our intestinal microbiota is highly variable and influenced by multiple factors, of which diet is one of the major elements. Between 1970 and 1990, diet composition has changed and consumption of dietary sugars has increased, of which fructose intake rose by more than 10-fold. This increased intake of sugars and fructose is considered as one of the major risk factors in the developments of obesity and several metabolic disturbances. In this review, we describe the association of dietary fructose intake with insulin resistance, nonalcoholic fatty liver disease (NAFLD) and lipid metabolism. Moreover, we will focus on the potential causality of this altered gut microbiota using fecal transplantation studies in human metabolic disease and whether fecal microbial transplant can reverse this phenotype.