Asymmetric preparation of 2,4,6‐trisubstituted dihydropyridazinones

Modular three‐component synthesis of highly enantioenriched 2,4,6‐trisubstituted dihydropyridazinones was developed through the nucleophilic substitution of α‐bromoacetates with silyl enol ethers and subsequent condensation with hydrazine derivatives. Highly enantioenriched 2,4,6‐trisubstituted dihy...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 44; no. 1; pp. 73 - 78
Main Authors Park, Min Ji, Kim, Seo Yun, Lee, Ha Rim, Park, Yong Sun
Format Journal Article
LanguageEnglish
Published Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.01.2023
대한화학회
Subjects
4,5‐dihydropyridazin‐3‐one
asymmetric synthesis
carbon–carbon bond formation
chiral auxiliary
modular synthetic strategy
화학
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ISSN1229-5949
0253-2964
1229-5949
DOI10.1002/bkcs.12630

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Summary:Modular three‐component synthesis of highly enantioenriched 2,4,6‐trisubstituted dihydropyridazinones was developed through the nucleophilic substitution of α‐bromoacetates with silyl enol ethers and subsequent condensation with hydrazine derivatives. Highly enantioenriched 2,4,6‐trisubstituted dihydropyridazinones are prepared by a modular three‐component synthetic strategy.
Bibliography:Funding information
National Research Foundation of Korea, Grant/Award Number: NRF‐2020R1F1A1049676
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.12630