Synthesis of Idebenonyl Ester Prodrugs and Their Evaluation of Cancer Cells In Vitro

Esterification of idebenone with commercially available straight‐chain aliphatic acids, branched‐chain aliphatic acids, aromatic acids, or nonsteroidal anti‐inflammatory drugs afforded their corresponding idebenonyl esters (5a–k) in good yield. The values of cell viability for RC‐58T cell at 50 μM w...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 42; no. 4; pp. 559 - 562
Main Authors Bae, Song Mi, Choi, Se Myeong, Won, Yeong‐seon, Seo, Kwon‐il, Jung, Dai il, Song, Ju Hyun, Cho, Jong Hyun
Format Journal Article
LanguageEnglish
Published Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.04.2021
대한화학회
Subjects
Cancer cells
Cell viability
Idebenone
Idebenonyl ester
Prodrugs
화학
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ISSN1229-5949
0253-2964
1229-5949
DOI10.1002/bkcs.12246

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Summary:Esterification of idebenone with commercially available straight‐chain aliphatic acids, branched‐chain aliphatic acids, aromatic acids, or nonsteroidal anti‐inflammatory drugs afforded their corresponding idebenonyl esters (5a–k) in good yield. The values of cell viability for RC‐58T cell at 50 μM were 86.3% for 5a, 75.9% for 5b, 23.4% for 5d, 61.2% for 5f, 67.9% for 5h, 70.6% for 5i, and 49.0% for 5j. Idebenonyl ester prodrugs (5a–k) were prepared using esterification of idebenone with commercially available acid analogs (4a–k). Specifically, the value of cell viability of compound 5b for RC‐58T cell at 50 μM was 23.4%.
Bibliography:Ju Hyun Song and Jong Hyun Cho contributed equally to this work.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.12246