Synthesis and Evaluation of Novel 3‐Allylseleno‐6‐Alkylsulfonylpyridazine Derivatives with Potential Anticancer Properties
A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The sy...
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| Published in | Bulletin of the Korean Chemical Society Vol. 38; no. 11; pp. 1327 - 1332 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
Wiley‐VCH Verlag GmbH & Co. KGaA
01.11.2017
대한화학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1229-5949 0253-2964 1229-5949 |
| DOI | 10.1002/bkcs.11292 |
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| Abstract | A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The synthesis involved thiolation, oxidation, selenylation, and Se‐allylation of alkylthiols. That is, sodium methanethiolate, ethanethiol, propanethiol, butanethiol, pentanethiol, and hexanethiol were inserted into the 6‐position of the pyridazine nucleus. These new synthetic compounds exhibited antiproliferative activity against human breast cancer (MCF‐7), hepatocarcinoma (Hep3B), and human colon carcinoma (RKO) cells in CCK‐8 assays, and are potential candidates for cancer chemotherapy. |
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| AbstractList | A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The synthesis involved thiolation, oxidation, selenylation, and Se‐allylation of alkylthiols. That is, sodium methanethiolate, ethanethiol, propanethiol, butanethiol, pentanethiol, and hexanethiol were inserted into the 6‐position of the pyridazine nucleus. These new synthetic compounds exhibited antiproliferative activity against human breast cancer (MCF‐7), hepatocarcinoma (Hep3B), and human colon carcinoma (RKO) cells in CCK‐8 assays, and are potential candidates for cancer chemotherapy. A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The synthesis involved thiolation, oxidation, selenylation, and Se‐allylation of alkylthiols. That is, sodium methanethiolate, ethanethiol, propanethiol, butanethiol, pentanethiol, and hexanethiol were inserted into the 6‐position of the pyridazine nucleus. These new synthetic compounds exhibited antiproliferative activity against human breast cancer ( MCF ‐7), hepatocarcinoma ( Hep3B ), and human colon carcinoma ( RKO ) cells in CCK ‐8 assays, and are potential candidates for cancer chemotherapy. A new series of 3-allylseleno-6-alkylsulfonylpyridazines and 3-allylseleno-6-alkylsulfinylpyridazines were synthesized from 3,6-dichloropyridazine for anticancer agent development. The inhibitory effects of 3-allylseleno-6-alkylsulfonylpyridazines on human cancer cell lines were investigated. The synthesis involved thiolation, oxidation, selenylation, and Se-allylation of alkylthiols. That is, sodium methanethiolate, ethanethiol, propanethiol, butanethiol, pentanethiol, and hexanethiol were inserted into the 6-position of the pyridazine nucleus. These new synthetic compounds exhibited antiproliferative activity against human breast cancer (MCF-7), hepatocarcinoma (Hep3B), and human colon carcinoma (RKO) cells in CCK-8 assays, and are potential candidates for cancer chemotherapy. KCI Citation Count: 1 |
| Author | Kim, Chaewon Park, Myung‐Sook |
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| CitedBy_id | crossref_primary_10_1002_chem_202302156 crossref_primary_10_1016_j_ejmech_2020_112946 |
| Cites_doi | 10.1007/s12272-016-0878-6 10.1039/a809656b 10.1081/SCC-120003627 10.1016/j.bmcl.2011.06.122 10.1002/bkcs.10635 10.1016/j.ejmech.2011.02.002 10.1007/s12272-013-0244-x 10.1002/bkcs.10319 10.3109/10520299509108199 10.1016/0022-1759(95)00072-I 10.1007/s12272-014-0416-3 10.1016/j.jorganchem.2004.07.040 10.1016/j.ejmech.2008.09.047 10.1007/s12272-014-0407-4 10.1016/S0022-328X(02)01627-3 10.5012/bkcs.2013.34.11.3317 10.5012/bkcs.2014.35.5.1533 10.5012/jkcs.2011.55.3.546 10.1016/j.bmcl.2009.04.061 10.1002/bkcs.10967 10.1007/BF02977666 |
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| SubjectTerms | 3‐Allylseleno‐6‐alkylsulfonylpyridazines Antiproliferative Apoptosis Organoselenium Compounds 화학 |
| Title | Synthesis and Evaluation of Novel 3‐Allylseleno‐6‐Alkylsulfonylpyridazine Derivatives with Potential Anticancer Properties |
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