Synthesis and Evaluation of Novel 3‐Allylseleno‐6‐Alkylsulfonylpyridazine Derivatives with Potential Anticancer Properties

A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The sy...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 38; no. 11; pp. 1327 - 1332
Main Authors Kim, Chaewon, Park, Myung‐Sook
Format Journal Article
LanguageEnglish
Published Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.11.2017
대한화학회
Subjects
3‐Allylseleno‐6‐alkylsulfonylpyridazines
Antiproliferative
Apoptosis
Organoselenium Compounds
화학
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ISSN1229-5949
0253-2964
1229-5949
DOI10.1002/bkcs.11292

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Summary:A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The synthesis involved thiolation, oxidation, selenylation, and Se‐allylation of alkylthiols. That is, sodium methanethiolate, ethanethiol, propanethiol, butanethiol, pentanethiol, and hexanethiol were inserted into the 6‐position of the pyridazine nucleus. These new synthetic compounds exhibited antiproliferative activity against human breast cancer (MCF‐7), hepatocarcinoma (Hep3B), and human colon carcinoma (RKO) cells in CCK‐8 assays, and are potential candidates for cancer chemotherapy.
Bibliography:http://onlinelibrary.wiley.com/doi/10.1002/bkcs.11292/abstract
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.11292