Effect of SCH55700, a Humanized Anti-Human Interleukin-5 Antibody, in Severe Persistent Asthma: A Pilot Study

• Published in: American journal of respiratory and critical care medicine Vol. 167; no. 12; pp. 1655 - 1659
• Main Authors: Kips, Johan C, O'Connor, Brian J, Langley, Stephen J, Woodcock, Ashley, Kerstjens, Huib A. M, Postma, Dirkje S, Danzig, Mel, Cuss, Francis, Pauwels, Romain A
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.06.2003; American Lung Association; American Thoracic Society
• Subjects: Adult; Analysis of Variance; Anti-Asthmatic Agents - immunology; Anti-Asthmatic Agents - pharmacokinetics; Anti-Asthmatic Agents - therapeutic use; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacokinetics; Antibodies, Monoclonal - therapeutic use; Asthma - complications; Asthma - drug therapy; Asthma - immunology; Biological and medical sciences; Double-Blind Method; Drug Monitoring; Eosinophilia - blood; Eosinophilia - etiology; Eosinophils - drug effects; Eosinophils - immunology; Female; Forced Expiratory Volume - drug effects; Humans; Immunoglobulin G - immunology; Infusions, Intravenous; Injections, Intravenous; Interleukin-5 - antagonists & inhibitors; Interleukin-5 - immunology; Leukocyte Count; Male; Medical sciences; Pharmacology. Drug treatments; Pilot Projects; Respiratory system; Safety; Severity of Illness Index; Treatment Outcome; Human; Prognosis; Respiratory disease; Antibody; Bronchodilator; Cytokine; glucocorticosteroids; Asthma; interleukin-5; Chemotherapy; Interleukin 5; Treatment; Follow up study; Severity score; Obstructive pulmonary disease; anti-human interleukin-5 antibody; eosinophil
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/rccm.200206-525OC

Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700, a humanized anti-human IL-5 antibody, in subjects with severe persistent asthma treated with oral or high doses of inhaled steroids. In a double-blind, randomized, multicenter trial, a rising single dose of SCH55700 (0.03 mg/kg [n = 2], 0.1 mg/kg [n = 4], 0.3 mg/kg [n = 6], or 1.0 mg/kg [n = 12]) or placebo (n = 8) was administered intravenously. SCH55700 dose dependently reduced circulating eosinophil counts. At a dose of 1.0 mg/kg, the decrease remained significant up to Day 30 [(0.07 +/- 0.01) x 10(9)/L versus (0.23 +/- 0.04) x 10(9)/L at baseline] (mean +/- SEM) (p = 0.05). After administration of SCH55700 at 0.3 and 1.0 mg/kg, a trend toward improvement in baseline FEV1 was observed, which reached significance 24 hours after the 0.3-mg/kg dose (p = 0.019 versus placebo). No significant changes occurred in other clinical indices of disease activity. Adverse events were not different between active treatment and placebo. We conclude that SCH55700 is a biologically active anti-human IL-5 antibody that can be safely used in severe steroid-treated asthma. Its therapeutic potential needs to be addressed in specifically designed efficacy trials.