A case of hepatocellular carcinoma in primary biliary cirrhosis positive for anti-HCV

• Published in: Kanzo Vol. 33; no. 2; pp. 167 - 173
• Main Authors: HATA, Kojiro, HATAKEYAMA, Shigeaki, OHKOSHI, Showgo, HATANO, Toru, KAMIMURA, Tomoteru, ICHIDA, Takafumi, AOYAGI, Yutaka, NAGAYAMA, Shosbiro, NOMOTO, Minoru, HAYAKAWA, Akihito
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1992
• ISSN: 0451-4203; 1881-3593; 1881-3593
• DOI: 10.2957/kanzo.33.167

We report a case of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC) positive for anti-HCV. A 63-year-old woman with a history of blood transfusion was admitted to the hospital in April 1986 for hepatic encephalopathy, and diagnosed as liver cirrhosis. Since December 1987 she had been followod up with a dianosis of PBC because of elevated level of alkaline phosphatase, positive for anti-mitochondrial antibody and pruritus. In March 1990 she was readmitted for occurrence of general malaise and elevated level of alpha-fetoprotein. Abdominal US and CT demonstrated two tumors measuring 2.5cm in diameter at S6 and S8 in the liver, and celiac angiography revealed hypervascular lesions in the same areas. Histology obtained from tumor biopsy showed well-differentiated HCC, and laparoscopic liver biopsy showed PBC (Scheuer's stage 4). The test on hepatitis viruses markers was negatiVe for HBsAg but positive for anti-HCV (C-100). HCV infection was confirmed in this patient by positive anti-HCV core and detection of HCV RNA as well as anti-HCV. It was suggested that there were some relations between the chronic HCV infection and the occurrence of HCC in PBC.