Electrostatic Interactions Determining the Selectivity of KcsA Channel and Its Mutants
We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine...
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| Published in | Chinese physics letters Vol. 27; no. 8; pp. 264 - 266 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
IOP Publishing
01.08.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0256-307X 1741-3540 |
| DOI | 10.1088/0256-307X/27/8/088701 |
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| Abstract | We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine the selectivity of the channel. |
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| AbstractList | We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K+ channels, determine the selectivity of the channel. We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine the selectivity of the channel. |
| Author | 刘玉芝 安海龙 张素花 于慧 展永 张海林 |
| AuthorAffiliation | Institute of Biophysics, Hebei University of Technology, Tianjin 300130 Departments of Pharmacology, Hebei Medical University, Shijiazhuang 050017 |
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| Cites_doi | 10.1088/0256-307X/25/9/020 10.1088/1009-1963/15/7/034 10.1529/biophysj.108.136556 10.1016/S0006-3495(00)76831-7 10.1088/0256-307X/23/8/031 10.1126/science.280.5360.69 10.1016/j.jmb.2009.04.038 10.1126/science.1133415 10.1038/35009114 10.1038/nsmb1311 10.1016/S0006-3495(94)80887-2 10.7498/aps.57.4153 10.1088/0256-307X/25/4/029 10.1111/j.1469-7793.2001.0021m.x |
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| DocumentTitleAlternate | Electrostatic Interactions Determining the Selectivity of KcsA Channel and Its Mutants |
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| References | Zhan Y (9) 2006; 23 Xie Z (12) 2008; 25 Frisch M J (14) 2003 15 An H L (8) 2005; 32 16 1 2 Yang K (11) 2006; 15 3 4 5 6 7 Sheng Y (13) 2008; 57 An H L (10) 2008; 25 |
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| Snippet | We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our... |
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| StartPage | 264 |
| SubjectTerms | Cations Channels Density functional theory Electrostatics Selectivity Signatures Simulation Three dimensional 三维结构 信道选择 密度泛函理论 测定 特征序列 离子通道 突变体选择 静电相互作用 |
| Title | Electrostatic Interactions Determining the Selectivity of KcsA Channel and Its Mutants |
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