Electrostatic Interactions Determining the Selectivity of KcsA Channel and Its Mutants

We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine...

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Bibliographic Details
Published inChinese physics letters Vol. 27; no. 8; pp. 264 - 266
Main Author 刘玉芝 安海龙 张素花 于慧 展永 张海林
Format Journal Article
LanguageEnglish
Published IOP Publishing 01.08.2010
Subjects
Cations
Channels
Density functional theory
Electrostatics
Selectivity
Signatures
Simulation
Three dimensional
三维结构
信道选择
密度泛函理论
测定
特征序列
离子通道
突变体选择
静电相互作用
Online AccessGet full text
ISSN0256-307X
1741-3540
DOI10.1088/0256-307X/27/8/088701

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Summary:We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine the selectivity of the channel.
Bibliography:11-1959/O4
S66
O647.2
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ISSN:0256-307X
1741-3540
DOI:10.1088/0256-307X/27/8/088701