Expressions of MGMT and Survivin in Colorectal Carcinoma

• Published in: Chinese journal of cancer research Vol. 20; no. 2; pp. 139 - 143
• Main Author: 祁晓莉 王发亮 薄爱华 侯金超 牛书雷
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Anti-Cancer Association 01.06.2008; Department of Pathology,Daxing Hospital,Beijing 102600%The University Student's Associationyo for Scientific Research,Hebei North University%Department of Electron Microscope,Hebei North University,Zhangjiakou 075029
• Subjects: Medicine; Medicine & Public Health; MGMT; 结肠癌; R735.3; Polypus of large intestine; Survivin; O6-methyguanine-DNA methytransferase (MGMT); 5; Colorectal carcinoma; O6-methyguanine-DNA methytransferase(MGMT)
• ISSN: 1000-9604; 1993-0631
• DOI: 10.1007/s11670-008-0139-4

Objective： To investigate the expressions of O6-methyguanine-DNA methytransferase（MGMT） and Survivin in colorectal carcinoma and their clinical significance. Methods： Formalin-fixed, paraffin-embedded specimens from polypus and colorectal carcinoma were examined with streptavidin-biotin peroxidase（S-P） immunohistochemical technique for the expressions of MGMT and Survivin. Results： We found that there were significant differences in MGMT and Survivin between polypus and colorectal carcinoma. Expression of MGMT was correlated with ages and lymph node metastasis while Survivin was associated with lymph node metastasis only. Meanwhile, the expression of MGMT was correlated with Survivin （P〈0.01, r=0.65）. But there was no significant difference between male and female and the different depth of infiltration. Conclusion： It is concluded that the abnormal expressions of MGMT and Survivin were associated with the degree of malignancy of colorectal tumor. They possibly could be useful indexes for the primary screening and prognosis of colorectal carcinoma. Examination of them may have an important guiding significance in the chemotherapy strategy.