RNA Polymerase, a Scrunching Machine

Recent research illuminates the initial steps of making an RNA chain by showing how the energy of nucleoside triphosphate hydrolysis is captured to break the enzyme loose from its tight contact with DNA. RNA polymerase stores energy to break its initial bonds with DNA by scrunching the single strand...

Full description

Saved in:
Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 314; no. 5802; pp. 1097 - 1098
Main Author Roberts, Jeffrey W.
Format Journal Article
LanguageEnglish
Published Washington American Association for the Advancement of Science 17.11.2006
The American Association for the Advancement of Science
Subjects
Biochemistry
Deoxyribonucleic acid
DNA
Enzymes
Gene expression
Melting
Modeling
Nucleotides
Perspectives
Promoter regions
RNA
RNA polymerase
Single stranded DNA
Online AccessGet full text
ISSN0036-8075
1095-9203
DOI10.1126/science.1135746

Cover

More Information
Summary:Recent research illuminates the initial steps of making an RNA chain by showing how the energy of nucleoside triphosphate hydrolysis is captured to break the enzyme loose from its tight contact with DNA. RNA polymerase stores energy to break its initial bonds with DNA by scrunching the single strands of DNA that were unwound in the region where the polymerase started RNA synthesis.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Commentary-2
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1135746