Disposition of Furosemide and Diuretic Response in Man

Four doses (5, 10, 20, 40mg) of furosemide were orally administered to 3 healthy male subjects. Urine samples were collected after predetermined time intervals and urinary excretions of the drug, Na+ and K+ were determined as well as urine volumes. Linear relationship was observed between increments...

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Published inYAKUGAKU ZASSHI Vol. 106; no. 3; pp. 221 - 227
Main Authors KATAYAMA, KAZUNORI, KAKEMI, MASAWO, ZHU, JIABI, KOIZUMI, TAMOTSU
Format Journal Article
LanguageJapanese
Published Japan The Pharmaceutical Society of Japan 01.03.1986
Subjects
Adult
Diuresis - drug effects
diuretic response
diuretics
Dose-Response Relationship, Drug
furosemide
Furosemide - metabolism
Furosemide - pharmacology
Humans
Kinetics
Male
Middle Aged
pharmacokinetic analysis
pharmacokinetics
pharmacologic response
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ISSN0031-6903
1347-5231
DOI10.1248/yakushi1947.106.3_221

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Summary:Four doses (5, 10, 20, 40mg) of furosemide were orally administered to 3 healthy male subjects. Urine samples were collected after predetermined time intervals and urinary excretions of the drug, Na+ and K+ were determined as well as urine volumes. Linear relationship was observed between increments ofcumulative Na++K+ excretion and urine volumes. Durations of diuretic response were about 3 h regardless of the dose administered, thereafter, Na++K+ excretions and urine volumes were below control levels. Three-hour cumulations of urinary Na++K+ excretion increments were linearly related to logarithm of the amount of furosemide administered.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.106.3_221