Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA

• Published in: Journal of Pediatric Endocrinology and Metabolism Vol. 26; no. 9-10; p. 883
• Main Authors: Shiva, Siamak, Behbod, Haleh, Ghergherechi, Robabeh
• Format: Journal Article
• Language: English
• Published: Germany 2013
• Subjects: Adolescent; Child; Child Development; Child, Preschool; Cross-Sectional Studies; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - drug therapy; Diabetic Ketoacidosis - prevention & control; Down-Regulation - drug effects; Drug Resistance; Female; Hospitals, Pediatric; Humans; Hypoglycemic Agents - therapeutic use; Infant; Insulin - therapeutic use; Insulin-Like Growth Factor I - analysis; Male; Severity of Illness Index; Up-Regulation - drug effects
• ISSN: 0334-018X; 2191-0251; 2191-0251
• DOI: 10.1515/jpem-2013-0057

The issue of insulin-like growth factor 1 (IGF-1) and diabetes in adults and type 2 diabetes has been well investigated. A few studies have investigated the serum IGF-1 level at the onset of type 1 diabetes mellitus (T1DM) in children. In the present study, we investigated the IGF-1 level of T1DM children before and after insulin therapy. Between August 2011 and October 2012, 62 children with newly diagnosed T1DM were recruited. Serum IGF-1 levels were compared before and 1 month after insulin therapy between diabetic ketoacidosis (DKA) and non-DKA patients. Thirty-one patients without DKA (18 girls and 13 boys, mean age 8.8 ± 3.01 years) and 31 patients with DKA (18 girls and 13 boys, mean age 8.3 ± 3.7 years) were studied. The mean IGF-1 in the DKA group was lower than that in the non-DKA group; however, this difference was not statistically significant (p=0.10). Serum IGF-1 levels increased significantly 1 month after insulin therapy in both the DKA (p<0.001) and non-DKA (p<0.001) groups. Serum IGF-1 level is reduced in new-onset T1DM children. A significant increase in serum IGF-1 level can occur with insulin therapy in both DKA and non-DKA children.