Plasma Fibrinogen, Cholinesterase Activity, and Anemia: Utility of Fibrinogen in Multiphasic Screening and in Assessing the Activity of Diseases

I present the general pattern relationships between (a) plasma fibrinogen and cholinesterase activity and (b) plasma fibrinogen and hemoglobin, in 250 and 310 hos-pitalized adults, respectively. Although responses of cholinesterase were often unrelated to fibrinogen, when its activity in plasma was...

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Bibliographic Details
Published inClinical chemistry (Baltimore, Md.) Vol. 23; no. 4; pp. 741 - 742
Main Author Rice, Eugene W
Format Journal Article
LanguageEnglish
Published England 01.01.1977
Subjects
Acute Disease
Adult
Anemia - diagnosis
Cholinesterases - blood
Fibrinogen - analysis
Hemoglobinometry
Humans
Multiphasic Screening
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ISSN0009-9147
1530-8561
DOI10.1093/clinchem/23.4.741

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Summary:I present the general pattern relationships between (a) plasma fibrinogen and cholinesterase activity and (b) plasma fibrinogen and hemoglobin, in 250 and 310 hos-pitalized adults, respectively. Although responses of cholinesterase were often unrelated to fibrinogen, when its activity in plasma was depressed, above-normal fi-brinogen concentrations were present in about 90% of the subjects. Further, despite the observed independence of hemoglobin and fibrinogen concentrations, whenever frank anemia was present (hemoglobin < 110 to 120 g/liter), hyperfibrinogenemia was also present in about 75-85% of such anemic patients. Thus, these studies affirm that fibrinogen determination would be an appropriate com-ponent of tests on hospital admission and also that hyp-erfibrinogenemia is a very sensitive "acute phase" reactant, and an important reaction for gauging the course of numerous disorders.
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ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/23.4.741