Genetic Alterations in Colorectal Tumorgenesis

Recent studies revealed that multiple alterations of oncogenes and tumor suppressor genes were accumulated during development of colorectal tumor. Activation of Ki-ras oncogene with point mutation is frequently detected in malignant tumors, as well as, in benign adenomas. Based on detailed studies o...

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Published inNippon Daicho Komonbyo Gakkai Zasshi Vol. 44; no. 8; pp. 1195 - 1199
Main Authors Ando, H., Miki, Y., Miyoshi, Y., Nagase, H., Nishisho, I., Horii, A., Nakamura, Y.
Format Journal Article
LanguageEnglish
Japanese
Published The Japan Society of Coloproctology 1991
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ISSN0047-1801
1882-9619
DOI10.3862/jcoloproctology.44.1195

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Summary:Recent studies revealed that multiple alterations of oncogenes and tumor suppressor genes were accumulated during development of colorectal tumor. Activation of Ki-ras oncogene with point mutation is frequently detected in malignant tumors, as well as, in benign adenomas. Based on detailed studies on chromosomal deletions in tumor, two candidate tumor suppressor genes, p53 on chromosome 17p and DCC gene on chromosome 18q, were identified. These two genes are often inactivated in colorectal cancers by deletion, point mutation or insertion. Cytogenetic and linkage studies have shown that chromosomal region 5q21 harbors the gene responsible for familial adenomatous polysosis (FAP). Furthermore, this chromosomal region is often deleted in sporadic colorectal tumors. Recently, we have isolated a gene (MCC gene) located at 5q21 region that is mutated in colorectal cancers and a candidate for the putative colorectal tumor suppressor gene.
ISSN:0047-1801
1882-9619
DOI:10.3862/jcoloproctology.44.1195