WM-OA-ICOS Based Mid-infrared Dual-range Real-time Trace Sensor for Formaldehyde Detection in Exhaled Breath

Based on Wavelength Modulation Spectroscopy and Off-Axis Integrated Cavity Output Spectroscopy (WM-OA-ICOS), a highly sensitive dual-range real-time formaldehyde (CH 2 O) detection trace sensor was developed to detect CH 2 O in human exhaled breath, which can realize the early screening of lung canc...

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Bibliographic Details
Published inIEEE sensors journal Vol. 23; no. 1; p. 1
Main Authors Li, Guolin, Song, Yimeng, Ma, Kun, Zhang, Xuena, Zhao, Hao, Zhang, Zecheng, Liu, Yajing, Wu, Yunhui, Li, Jiarui, Zhai, Shenqiang, Li, Qiang, Zheng, Kaiyuan, Zheng, Chuantao
Format Journal Article
LanguageEnglish
Published New York IEEE 01.01.2023
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Absorption
Algorithms
CEEMDAN
Dual-range detection
Empirical analysis
Formaldehyde
Laser beams
Lung cancer
Mirrors
PSO-LSSVM
Quantum cascade laser
Quantum cascade lasers
Real time
Sensitivity
Sensors
Signal to noise ratio
Spectroscopy
Spectrum analysis
Wavelength modulation
WM-OA-ICOS
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ISSN1530-437X
1558-1748
DOI10.1109/JSEN.2022.3210230

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Summary:Based on Wavelength Modulation Spectroscopy and Off-Axis Integrated Cavity Output Spectroscopy (WM-OA-ICOS), a highly sensitive dual-range real-time formaldehyde (CH 2 O) detection trace sensor was developed to detect CH 2 O in human exhaled breath, which can realize the early screening of lung cancer. And a 5.85 μm quantum cascade laser (QCL) and an off-axis integrated cavity were adopted. Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) is applied to improve the signal-to-noise ratio (SNR), and the sensor is embedded with a high-precision concentration inversion algorithm. The reliability of the sensor was verified by experiments with interfering gases in exhaled breath, and the results showed the sensor has an excellent detection accuracy. The limits of detection (LoD) is ~140 parts per trillion (ppt) with an 88 s integration time by Allan-Werle deviation analysis. The experimental results of exhaled gas showed that the concentration of CH 2 O exhaled from different subjects was significantly different. Therefore, the sensor provides a promising way for real-time detection of CH 2 O concentration in human exhaled breath.
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ISSN:1530-437X
1558-1748
DOI:10.1109/JSEN.2022.3210230