Clinical Courses of Primary Hepatic Angiosarcoma: Retrospective Analysis of Eight Cases

• Published in: The Korean journal of gastroenterology Vol. 65; no. 4; pp. 229 - 235
• Main Authors: Hur, Chang Jae, Min, Bo Ram, Lee, Yoo Jin, Jang, Byung Kuk, Hwang, Jae Seok, Kim, Eun Soo, Park, Kyung Sik, Cho, Kwang Bum, Kang, Yu Na, Chung, Woo Jin
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한소화기학회 01.04.2015
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - therapeutic use; Embolization, Therapeutic; Female; Hemangiosarcoma - diagnosis; Hemangiosarcoma - pathology; Hemangiosarcoma - therapy; Humans; Immunohistochemistry; Liver Neoplasms - diagnosis; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Retrospective Studies; Survival Rate; Tomography, X-Ray Computed; 내과학; Hepatic angiosarcoma; Liver neoplasms
• ISSN: 1598-9992; 2233-6869; 2233-6869
• DOI: 10.4166/kjg.2015.65.4.229

Hepatic angiosarcoma, a rare and aggressive liver malignancy, is difficult to diagnose because of a lack of specific clinical features. The clinical and radiological features of patients with histologically confirmed hepatic angiosarcoma were examined. Among 2,336 patients diagnosed with primary hepatic carcinoma at Keimyung University Dongsan Medical Center (Daegu, Korea) between May 2002 and February 2012, eight (0.03%) with histologically confirmed primary hepatic angiosarcoma were included. The patterns of disease diagnosis, tumor characteristics, treatment responses, and prognoses were reviewed retrospectively. Median age was 66 years-old (range, 41-80 years). Four patients were male. Five patients were compulsive drinkers. All patients had no HBsAg and anti-HCV. Initial radiologic diagnoses revealed primary hepatic angiosarcoma (n=2), hepatocellular carcinoma (n=2), hemangioma (n=2), and hepatic metastatic carcinoma (n=2). Definitive diagnoses were made by percutaneous needle biopsies in seven patients and surgical resection in one patient. At the time of the initial diagnosis, extrahepatic metastases were detected in three patients (37.5%). Metastatic sites included the spleen and lung, pericardium, and bone, in one patient each. Two patients underwent conservative treatments. The remaining patients underwent surgical resection (n=1), transcatheter arterial chemoembolization (n=1), and systemic chemotherapy (n=4). The median survival period was 214 days (range, 21-431 days). Hepatic angiosarcoma is a highly progressive disease with a poor prognosis. Detailed studies including histological examinations are essential to facilitate early diagnosis of the disease.