A Case of Sorafenib-induced DRESS Syndrome in Hepatocelluar Carcinoma

Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms...

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Published inThe Korean journal of gastroenterology Vol. 67; no. 6; pp. 337 - 340
Main Authors Kim, Dong Kyun, Lee, Sung Woo, Nam, Hwa Seong, Jeon, Dong Sub, Park, Na Rae, Nam, Young Hee, Lee, Soo Keol, Baek, Yang Hyun, Han, Sang Young, Lee, Sung Wook
Format Journal Article
LanguageEnglish
Published Korea (South) Jin Publishing & Printing Co 25.06.2016
대한소화기학회
Subjects
DRESS syndrome
Hepatocellular carcinoma
Sorafenib
내과학
DRESS syndrome
Hepatocellular carcinoma
Sorafenib
Online AccessGet full text
ISSN1598-9992
2233-6869
DOI10.4166/kjg.2016.67.6.337

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Summary:Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms (DRESS) syndrome. Here, we report a case of 72-year-old man with HCC and alcoholic liver cirrhosis who developed skin eruptions, fever, eosinophilia, and deteriorated hepatic and renal function under sorafenib treatment. He has since successfully recovered with conservative care.
Bibliography:G704-000307.2016.67.6.001
ISSN:1598-9992
2233-6869
DOI:10.4166/kjg.2016.67.6.337