Preclinical experimental models of drug metabolism and disposition in drug discovery and development
Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different s...
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| Published in | Acta pharmaceutica Sinica. B Vol. 2; no. 6; pp. 549 - 561 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier
01.12.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2211-3835 2211-3843 |
| DOI | 10.1016/j.apsb.2012.10.004 |
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| Abstract | Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different stages of drug discovery and development for determination of efficacy and safety. The proper selection and applications of correct models, as well as appropriate data interpretation, are critically important in decision making and successful advancement of drug candidates. In this review, we discuss strategies in the applications of both in vitro and in vivo experimental models of drug metabolism and disposition. |
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| AbstractList | Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different stages of drug discovery and development for determination of efficacy and safety. The proper selection and applications of correct models, as well as appropriate data interpretation, are critically important in decision making and successful advancement of drug candidates. In this review, we discuss strategies in the applications of both in vitro and in vivo experimental models of drug metabolism and disposition. |
| Author | Zhang, Donglu Lu, Chuang Luo, Gang Ding, Xinxin |
| Author_xml | – sequence: 1 givenname: Donglu surname: Zhang fullname: Zhang, Donglu – sequence: 2 givenname: Gang surname: Luo fullname: Luo, Gang – sequence: 3 givenname: Xinxin surname: Ding fullname: Ding, Xinxin – sequence: 4 givenname: Chuang surname: Lu fullname: Lu, Chuang |
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| SubjectTerms | ADME Caco-2 Drug metabolism and disposition Engineered mouse model Hepatocytes In vitro model Mass balance Preclinical |
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| Title | Preclinical experimental models of drug metabolism and disposition in drug discovery and development |
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