Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different s...

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Bibliographic Details
Published inActa pharmaceutica Sinica. B Vol. 2; no. 6; pp. 549 - 561
Main Authors Zhang, Donglu, Luo, Gang, Ding, Xinxin, Lu, Chuang
Format Journal Article
LanguageEnglish
Published Elsevier 01.12.2012
Subjects
ADME
Caco-2
Drug metabolism and disposition
Engineered mouse model
Hepatocytes
In vitro model
Mass balance
Preclinical
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ISSN2211-3835
2211-3843
DOI10.1016/j.apsb.2012.10.004

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Summary:Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different stages of drug discovery and development for determination of efficacy and safety. The proper selection and applications of correct models, as well as appropriate data interpretation, are critically important in decision making and successful advancement of drug candidates. In this review, we discuss strategies in the applications of both in vitro and in vivo experimental models of drug metabolism and disposition.
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2012.10.004