Cigarette smoking is associated with an increased risk of biochemical disease recurrence, metastasis, castration‐resistant prostate cancer, and mortality after radical prostatectomy Results from the SEARCH database

• Published in: Cancer Vol. 120; no. 2; pp. 197 - 204
• Main Authors: Moreira, Daniel M., Aronson, William J., Terris, Martha K., Kane, Christopher J., Amling, Christopher L., Cooperberg, Matthew R., Boffetta, Paolo, Freedland, Stephen J.
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley-Blackwell 15.01.2014
• Subjects: Aged; Biological and medical sciences; Disease-Free Survival; Georgia; Humans; Kaplan-Meier Estimate; Los Angeles; Male; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasm Recurrence, Local; North Carolina; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Prostatic Neoplasms, Castration-Resistant - mortality; Prostatic Neoplasms, Castration-Resistant - pathology; Prostatic Neoplasms, Castration-Resistant - surgery; Retrospective Studies; Risk Factors; Smoking - adverse effects; Tobacco, tobacco smoking; Toxicology; Tumors; North Carolina; Los Angeles; Georgia; Prostate disease; Tobacco smoking; Risk; Tumoral marker; Metastasis; Epidemiology; Biochemical recurrence; Prostate specific antigen; Association; Cancerology; Castration; Surgery; smoking; Database; Male genital diseases; Disease free survival; Urinary system disease; Mortality; Malignant tumor; Resistance; Tobacco; Treatment; disease-free survival; Risk factor; Prostatectomy; Prostate cancer; Cancer; prostate-specific antigen; prostate cancer; metastasis; mortality; prostatectomy; tobacco
• ISSN: 0008-543X; 1097-0142; 1097-0142
• DOI: 10.1002/cncr.28423

Cigarette smoking appears to be associated with an increased risk of metastasis, biochemical disease recurrence, castration‐resistant prostate cancer, and overall mortality. This suggests smoking is a modifiable risk factor for patients with aggressive prostate cancer.