A Simple and Efficient One-Pot Route for the Synthesis of 3-[1-Aryl(Alkyl)-2-Pyridin-2-yl-Ethyl]-4-Hydroxy-6-Methyl-2H-Pyran-2-Ones under Catalyst-Free Conditions

• Published in: Polycyclic aromatic compounds Vol. 42; no. 4; pp. 1879 - 1884
• Main Authors: Hoseinpour, Mahdieh, Mohebat, Razieh, Nateghi, Mohammad Reza, Kalantari Fotooh, Forough
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 21.04.2022; Taylor & Francis Ltd
• Subjects: 2-Methylpyridine; 3-[1-aryl(alkyl)-2-pyridin-2-yl-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-ones; 4-Hydroxy-6-methyl-2H-pyran-2-one; Aldehydes; Aromatic compounds; Biological activity; catalyst-free conditions; Catalysts
• ISSN: 1040-6638; 1563-5333
• DOI: 10.1080/10406638.2020.1815812

Reaction between 4-hydroxy-6-methyl-2H-pyran-2-one and aldehydes with 2-methylpyridine in dioxane under catalyst-free conditions provided a simple and efficient one-pot route for the synthesis of 3-[1-aryl(alkyl)-2-pyridin-2-yl-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-ones. The reaction is characterized by inexpensive and easily available starting materials, the formation of a single product, high yields of biologically active products, and a simple work-up process.