Stem Cell Research on Cardiology

• Format: eBook
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: 18F-FDG PET; 3D model; 3D printing; adult stem cells; Akt signaling; angiogenesis; arrhythmia; big conductance calcium activated potassium channel (BK); Biology, life sciences; biomarker; biomaterials; bioprinting; bioreactor; biostable polyurethane; bone marrow stem cells; cardiac cellular regeneration; cardiac differentiation; cardiac function; cardiac hypertrophy; cardiac induced cells; cardiac progenitor cells; cardiac regeneration; cardiac reprogramming; cardiac tissue engineering; cardiomyocyte proliferation; cardiomyocytes; cardioprotection; cardiovascular disease; cardiovascular diseases; cardiovascular medicine; coronary heart disease; CRISPR/Cas9 genomic editing; decorin; direct reprogramming; disease model; drug/toxicity screening; electrocardiography; electrospinning; endothelial progenitor cells; endothelialization; ESC; Fabry disease; fibronectin; field potential; genetic engineering; heart; heart valves; human embryonic stem cells; human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs); human pluripotent stem cell; hypertrophic cardiomyopathy; iberiotoxin; induced pluripotent stem cells; inflammation; iPS cells; iPSC; KCa1.1; leukocytes; long QT syndrome; Mass spectrometry proteomic analysis; Mathematics and Science; maturation; Maxi-K; MEA; mesenchymal stromal cells (MSC); meta-analysis; micro-electrode-array; MicroRNA; microRNA (miR); Mir-133; miRNA; mRNA; multi-electrode-array; myocardial infarction; myocardial infraction; myocarditis; myocardium; non-invasive imaging; physical exercise; PSC; Reference, Information and Interdisciplinary subjects; regeneration; Research and information: general; slo1; stem cells; tissue engineering; transdifferentiation; vascular graft; ventricular
• ISBN: 3039431927; 9783039431922; 3039431935; 9783039431939
• DOI: 10.3390/books978-3-03943-193-9

Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.