Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line

The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation....

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Published inBiomedical and environmental sciences Vol. 29; no. 3; pp. 224 - 228
Main Authors ZHU, Wu Yang, TAO, Xiao Yan, LYU, Xin Jun, YU, Peng Cheng, LU, Zhuo Zhuang
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2016
Subjects
293细胞
A型流感病毒
Cell Line
Gene Expression Regulation
HEK293 Cells
Humans
Influenza A virus - physiology
NS1蛋白
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
Virus Cultivation - methods
Virus Replication - physiology
甲型流感病毒
病毒复制
病毒粒子
细胞株
非结构蛋白
Online AccessGet full text
ISSN0895-3988
2214-0190
DOI10.3967/bes2016.028

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Summary:The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation. Compared with the parental 293 cells,
Bibliography:The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation. Compared with the parental 293 cells
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ISSN:0895-3988
2214-0190
DOI:10.3967/bes2016.028