The Initial Screening of Laryngeal Tumors via Voice Acoustic Analysis Based on Siamese Network Under Small Samples

• Published in: Journal of voice
• Main Authors: You, Zhenzhen, Sun, Delong, Shi, Zhenghao, Du, Shuangli, Hei, Xinhong, Kong, Demin, Du, Xiaoying, Yan, Jing, Ren, Xiaoyong, Hou, Jin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.05.2025
• Subjects: Initial screening of laryngeal tumors—Voice acoustic analysis—Mel-frequency cepstral coefficients—Siamese network; Otolaryngology; Initial screening of laryngeal tumors—Voice acoustic analysis—Mel-frequency cepstral coefficients—Siamese network
• ISSN: 0892-1997; 1873-4588; 1873-4588
• DOI: 10.1016/j.jvoice.2025.03.043

SummaryObjectiveThe initial screening of laryngeal tumors via voice acoustic analysis is based on the clinician’s experience that is subjective. This article introduces a Siamese network with an auxiliary gender classifier for automated, accurate, and objective initial screening of laryngeal tumors based on voice signals. MethodsThe study involved 71 tumor patients and 293 non-tumor subjects of Chinese Mandarin. This dataset was divided into a training set and a test set in a ratio of 4:1. We applied nine data augmentation techniques to enlarge the voice training set and extracted the corresponding mel-frequency cepstral coefficients (MFCC) maps. The MFCC maps were randomly paired and fed into the proposed Siamese network to achieve multitask classification for tumor and non-tumor, woman and man. The performance of the proposed model was compared with one machine learning method and six classical deep learning models with and without the auxiliary gender classifier. ResultsExperiments demonstrate the superiority of the proposed network compared with the reference models. The proposed model achieved an overall accuracy of 0.9437, an F score of 0.8462, a precision of 0.9167, a sensitivity of 0.7857, and a specificity of 0.9825. ConclusionThe proposed network can assist in the initial screening of laryngeal tumors through voice acoustic analysis. The initial screening solely through voice acoustic analysis can help individuals seek medical assistance outside the hospitals and reduce the burden on doctors as well.