Accurate and Efficient Algorithm for Detection of Alzheimer Disability Based on Deep Learning

• Published in: Cellular physiology and biochemistry Vol. 58; no. 6; pp. 739 - 755
• Main Authors: Alfayez, Fayez, Rozov, Sergey, El Tokhy, Mohamed S
• Format: Journal Article
• Language: English
• Published: Germany 19.12.2024
• Subjects: Aged; Algorithms; Alzheimer Disease - diagnosis; Alzheimer Disease - diagnostic imaging; Deep Learning; Diagnosis, Computer-Assisted - methods; Female; Humans; Male; Neural Networks, Computer; Support Vector Machine; Algorithms ; Alzheimer’s Disease ; Disability ; Deep Learning ; Alzheimer Disability
• ISSN: 1015-8987; 1421-9778; 1421-9778
• DOI: 10.33594/000000746

Background/Aims: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive functions and memory. Early detection is crucial for timely intervention and improved patient outcomes. However, traditional diagnostic tools, such as MRI and PET scans, are costly and less accessible. This study aims to develop an automated, cost-effective digital diagnostic approach using deep learning (DL) and computer-aided detection (CAD) methods for early AD identification and classification. Methods: The proposed framework utilizes pretrained convolutional neural networks (CNNs) for feature extraction, integrated with two classifiers: multi-class support vector machine (MSVM) and artificial neural network (ANN). A dataset categorized into four groups—non-demented, very mild demented, mild demented, and moderate demented—was employed for evaluation. To optimize the classification process, a texture-based algorithm was applied for feature reduction, enhancing computational efficiency and reducing processing time. Results: The system demonstrated high statistical performance, achieving an accuracy of 91%, precision of 95%, and recall of 90%. Among the initial set of twenty-two texture features, seven were identified as particularly effective in differentiating normal cases from mild AD stages, significantly streamlining the classification process. These results validate the robustness and efficacy of the proposed DL-based CAD system. Conclusion: This study presents a reliable and affordable solution for early AD detection and diagnosis. The proposed system outperforms existing state-of-the-art models and offers a valuable tool for timely treatment planning. Future research should explore its application to larger, more diverse datasets and investigate integration with other imaging modalities, such as MRI, to further enhance diagnostic precision.