Molecular dynamic simulation of the thermodynamic and kinetic properties of nucleotide base pair
A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to dir...
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| Published in | Chinese physics B Vol. 26; no. 12; pp. 1 - 6 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
01.12.2017
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| Online Access | Get full text |
| ISSN | 1674-1056 2058-3834 |
| DOI | 10.1088/1674-1056/26/12/128705 |
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| Summary: | A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods. |
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| Bibliography: | Yu-Jie Wang1,2, Zhen Wang1, Yan-Li Wang1, Wen-Bing Zhang1（1. Department of Physics, Wuhan University, Wuhan 430071, China;2. Department of Physics and Telecommunication Engineering, Zhoukou Normal University, Zhoukou 466000, China） A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods. thermodynamics; kinetics; molecular dynamic simulation 11-5639/O4 |
| ISSN: | 1674-1056 2058-3834 |
| DOI: | 10.1088/1674-1056/26/12/128705 |