Perioperative Coagulation Management and Control of Platelet Transfusion by Point-of-Care Platelet Function Analysis

• Published in: Transfusion medicine and hemotherapy Vol. 34; no. 6; pp. 396 - 411
• Main Authors: Görlinger, Klaus, Jambor, Csilla, Hanke, Alexander A., Dirkmann, Daniel, Adamzik, Michael, Hartmann, Matthias, Rahe-Meyer, Niels
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2007
• Subjects: Review Article · Übersichtsarbeit
• ISSN: 1660-3796; 1660-3818
• DOI: 10.1159/000109642

About one third of all blood components transfused intraoperatively is used in cardiac surgery, whereas mortality of cardiosurgical patients correlates nearly linear with the number of transfused units of packed red blood cells. Acquired platelet function disorders play a major role in perioperative bleeding in cardiac surgery. Therefore, the use of point-of-care-suitable platelet function analyzers seems to be reasonable in this field. Methods: Platelet function analyzer PFA-100®, rotational thrombelastometry (ROTEM®), and multiple platelet function analyzer (Multiplate®) are in principle applicable for point-of-care testing. Since these three analyzers monitor different aspects of platelet function and have different limitations, the selection of the right test system depends on the right question. Results: Perioperative use of platelet function analyzers is helpful in prediction of blood loss in cardiac surgery. Perioperative usage of blood components and their respective costs can be reduced by an appropriate coagulation management. Conclusion: Algorithms for perioperative coagulation management based on point-of-care testing permit a fast diagnostic and goal-directed therapy of coagulation and functional platelet disorders. The possibility to reduce the mortality of patients and the overall cost for hospital stay is subject of further studies.