Clinical efficacy of intrauterine platelet-rich plasma infusion in endometrial regeneration after hysteroscopic adhesiolysis: A retrospective cohort study

• Published in: Medicine (Baltimore) Vol. 104; no. 32; p. e43754
• Main Authors: Fan, Hui-Liu, Wu, Xiao-Xia, Wei, Hai-Chun, Zhang, Ying, Dou, Miao-Ling, Wei, Hong-Lan
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 08.08.2025
• Subjects: Adult; Endometrium - pathology; Endometrium - physiology; Female; Humans; Hysteroscopy - adverse effects; Hysteroscopy - methods; Observational Study; Platelet-Rich Plasma; Pregnancy; Pregnancy Rate; Regeneration; Retrospective Studies; Tissue Adhesions - surgery; Treatment Outcome; Uterine Diseases - surgery; Uterine Diseases - therapy; intrauterine adhesion; thin endometrium; platelet-rich plasma; intrauterine infusion
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000043754

The study investigated the effects of intrauterine infusion of platelet-rich plasma (PRP) on endometrial growth, repair of thin endometrium, and pregnancy outcomes following surgery for intrauterine adhesions (IUA). Fifty patients with severe IUA underwent hysteroscopic transcervical resection of adhesions (TCRA). Patients with normal uterine cavity morphology but thin endometrium on the second examination were selected for this observational study and divided into 2 groups of 25 each. The experimental group received intrauterine infusion of autologous PRP to promote endometrial growth, along with hormone replacement therapy, while the control group received only artificial menstrual cycle treatment. Endometrial thickness and blood flow values were observed in both groups 3 months post-surgery, and pregnancy outcomes were recorded within 1-year post-surgery. The experimental group showed slightly greater endometrial thickness than the control group; however, P > .05 indicated no statistically significant difference. Similarly, there was no significant difference in resistance index values between the 2 groups (P > .05). The pregnancy rate in the experimental group (36%) was higher than that in the control group (20%), but with P > .05, indicating no statistically significant difference. Intrauterine infusion of PRP for treating thin endometrium following severe IUA surgery did not significantly increase endometrial thickness or improve pregnancy rates.