Synthesis of 1,2,4,5-tetra-substituted benzenes via copper-catalyzed dimerization of γ,δ-unsaturated ketones

An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes via copper catalyzed dimerization of gamma,delta-unsaturated ketones has been described. This one-pot procedure employs the gamma,delta-unsaturated ketones as the sole substrate with multiple C-C bond formation. This pr...

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Published inChemical communications (Cambridge, England) Vol. 60; no. 60; pp. 7753 - 7756
Main Authors Ma, Kai-Xian, Hong, Chuan-Ming, Yan, Jiang-Min, Li, Qing-Hua, Liu, Tang-Lin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 23.07.2024
Royal Society of Chemistry
Subjects
Benzene
Chemical synthesis
Chemistry
Chemistry, Multidisciplinary
Copper
Covalent bonds
Dimerization
Ketones
Physical Sciences
Science & Technology
Substitutes
Substrates
CARBON
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ISSN1359-7345
1364-548X
1364-548X
DOI10.1039/d4cc02458c

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Summary:An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes via copper catalyzed dimerization of gamma,delta-unsaturated ketones has been described. This one-pot procedure employs the gamma,delta-unsaturated ketones as the sole substrate with multiple C-C bond formation. This protocol features broad substrate scope and provides a facile and robust method to construct polysubstituted benzene derivatives under mild conditions.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02458c