A long-term prognosis after interferon therapy for chronic hepatiti C
In this study, long term therapeutic effect of interferon (IFN) on chronic hepatitis (CH)-C was investigated. 252 patients with HCV-RNA were treated with 6MU of human lymphoblastoid alpha-IFN for 8 weeks, daily, followed by two or three times weekly and were followed for more than 2 years. 16 cases...
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Published in | Kanzo Vol. 37; no. 3; pp. 145 - 151 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | Japanese |
Published |
The Japan Society of Hepatology
1996
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Online Access | Get full text |
ISSN | 0451-4203 1881-3593 |
DOI | 10.2957/kanzo.37.145 |
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Summary: | In this study, long term therapeutic effect of interferon (IFN) on chronic hepatitis (CH)-C was investigated. 252 patients with HCV-RNA were treated with 6MU of human lymphoblastoid alpha-IFN for 8 weeks, daily, followed by two or three times weekly and were followed for more than 2 years. 16 cases were dropped out by IFN side effect ete. In remainder 236 cases, complete response (CR) were 105 cases (44.5%). In 31 cases of CR, 30 cases (96.8%) were improved in histological grading. The occurrence of hepatocellular carcinoma (HCC) in patients were 2 cases (0.8%) after termination of IFN. Those results indicate that CR cases could be improved histologically and IFN could have preventive effect on the development of HCC in chronic hepatis C. |
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ISSN: | 0451-4203 1881-3593 |
DOI: | 10.2957/kanzo.37.145 |