Combined transplantation of G-CSF primed allogeneic bone marrow cells and peripheral blood stem cells in treatment of severe aplastic anemia

• Published in: Chinese medical journal Vol. 117; no. 4; pp. 604 - 607
• Main Author: 黄晓军 陈育红 许兰平 张耀臣 刘代红 郭乃榄 陆道培
• Format: Journal Article
• Language: English
• Published: China Peking University Institute of Hematology, People's Hospital, Beijing 100044, China 01.04.2004
• Subjects: Adult; Anemia, Aplastic - mortality; Anemia, Aplastic - therapy; Bone Marrow Transplantation; Female; G-CSF; Graft vs Host Disease - etiology; Granulocyte Colony-Stimulating Factor - pharmacology; Hematopoietic Stem Cell Mobilization; Humans; Male; Middle Aged; Peripheral Blood Stem Cell Transplantation; Transplantation, Homologous; 外周血造血干细胞; 异基因移植; 重症再生障碍性贫血; 骨髓移植; hematopoietic stem cells transplantation; anemia,aplastic; granulocyte colony-stimulating factor; bone marrow
• ISSN: 0366-6999; 2542-5641

The major causes of unsuccessful transplantations for severe aplastic anemia (SAA) are graft-versus-host disease (GVHD), infection, and graft failure.^1,2 The latter is particularly associated with SAA in that various methods have been developed to overcome it.Intensification of immunosupression during conditioning and high-dosage stem cell infusion can overcome sensitization to transplant antigens and improve engraftment after transplantation.^3