Fabrication and characterization of nanopatterns for selective cell adhesion

• Published in: Journal of the Korean Physical Society Vol. 67; no. 4; pp. 706 - 712
• Main Author: Park, Soyeun
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Physical Society 01.08.2015; 한국물리학회
• Subjects: Mathematical and Computational Physics; Particle and Nuclear Physics; Physics; Physics and Astronomy; Theoretical; 물리학; AFM; Nanopattern; Nanosphere lithography; Adhesion
• ISSN: 0374-4884; 1976-8524
• DOI: 10.3938/jkps.67.706

Nanopatterns with chemical functionalization are of importance in biological sensing and drug delivery systems. Despite recent advances in nanotechnology, producing large-area nanopatterned surfaces for controlling the size of cellular adhesion sites is still a challenge. Unlike for homogeneous substrates, only a few techniques suitable for characterizing the chemical properties of nanopatterned substrates with a sufficient lateral resolution exist. In this research, we fabricated nanopatterned substrates composed of 2D arrays of gold nanoislands by using nanosphere lithography (NSL). Orthogonal chemistry was applied to achieve a selective adsorption of fibronectins to nanoislands. The contact angle and the X-ray photoelectron spectroscopy (XPS) data confirmed the success of the dual functionalization performed on 1/2Au-1/2glass substrates. The chemical properties of nanopatterns were investigated by using Atomic Force Microscopy (AFM). The adhesion maps and the topographic images confirmed nanometer-scale chemical functionalization.