Expression of HSP70 in Peripheral Lymphocytes of the Patients with Allergic Rhinitis

• Published in: Current medical science Vol. 23; no. 3; pp. 310 - 312
• Main Author: 刘立思 肖成峰 张明 程磊 王鄂芬 邬堂春
• Format: Journal Article
• Language: English
• Published: China Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030%Institute of Occupational Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030%Department of Otorhinolaryngology, Yi Ye Hospital, Wuhan 430081 2003
• Subjects: Adult; Female; Gene Expression Regulation; HSP70 Heat-Shock Proteins - biosynthesis; HSP70 Heat-Shock Proteins - blood; HSP70 Heat-Shock Proteins - genetics; Humans; Lymphocytes - metabolism; Male; Rhinitis, Allergic, Seasonal - blood; 淋巴细胞; 热休克蛋白-70; 蛋白表达; 过敏性鼻炎; heat shock protein 70; allergic rhinitis; lymphocyte
• ISSN: 1672-0733; 2096-5230; 2523-899X
• DOI: 10.1007/bf02829524

The expression levels of heat shock protein 70 (HSP70) from peripheral lymphoeytes of the patients with allergic rhinitis (AR) and the clinical implication were investigated. In the morning, 3 ml of fasting venous blood was taken out. The lymphocytes were isolated by using Ficoll-Hypaque and the expression of HSP70 in the lymphoeytes was detected by using Western blot. In the AR patients the HSP70 level (41.49±15.77 integrated optical density, IOD) were significantly higher than that in the control group (23.89±10.13 IOD, P<0.05). Western blot demonstrated that HSP70 bands in AR patients were more intensive than those in the control group. It was concluded that the elevated HSP70 level in peripheral lymphocytes of the AR patients might contribute to the development of AR.