Evaluation of simplified antipyrine test in calves

The purpose of this study was to test a modification of antipyrine test in calves. The experiment was carried out on 10 calves. Each subject received on days 10 and 20 of life, respectively, 15 mg.kg*[-1] body mass of antipyrine as an intravenous bolus injections, followed by its oral administration...

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Published inActa veterinaria Brno Vol. 66; no. 1; pp. 15 - 21
Main Authors Janus, K, Suszycka, J, Muszczynski, Z. (University of Agriculture, Szczecin (Poland))
Format Journal Article
LanguageEnglish
Published 01.03.1997
Subjects
ANTIPIRETICOS
ANTIPYRETICS
ANTIPYRETIQUE
APPLICATION METHODS
CALVES
MEDICINAL PROPERTIES
METHODE D'APPLICATION
METODOS DE APLICACION
PROPIEDADES MEDICINALES
PROPRIETE PHARMACOLOGIQUE
SALIVA
SALIVE
TERNERO
VEAU
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ISSN0001-7213
1801-7576
DOI10.2754/avb199766010015

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Summary:The purpose of this study was to test a modification of antipyrine test in calves. The experiment was carried out on 10 calves. Each subject received on days 10 and 20 of life, respectively, 15 mg.kg*[-1] body mass of antipyrine as an intravenous bolus injections, followed by its oral administration "in substantia" in gelatin capsules 48 hours later. The concentrations of antipyrine in their saliva were repeatedly detrmined. Based on the complete kinetics studies, mean variables for antipyrine were as follows: half-life -12.00+/-1.12 h, metabolic clearance-0.75+/-0.06 ml/min/kg (10-day-old calves) and 10.00+/-0.89 h; 0.80+/-0.07 ml/min/kg (20 day-old calves).
Bibliography:L70
1997001242
ISSN:0001-7213
1801-7576
DOI:10.2754/avb199766010015