Familial typical migraine: significant linkage and localization of a gene to Xq24–28

• Published in: Human genetics Vol. 107; no. 1; pp. 18 - 23
• Main Authors: Nyholt, Dale R., Curtain, Robert P., Griffiths, Lyn R.
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.07.2000; Berlin; New York, NY
• Subjects: Biological and medical sciences; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; Female; Fundamental and applied biological sciences. Psychology; Genetic Linkage; Genetic Markers; Genetics of eukaryotes. Biological and molecular evolution; Haplotypes; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Human; Humans; Lod Score; Male; Medical sciences; Migraine Disorders - genetics; Migraine with Aura - genetics; Migraine without Aura - genetics; Nervous system (semeiology, syndromes); Neurology; Pedigree; Recombination, Genetic; X Chromosome; Genetic mapping; Human; Nervous system diseases; Linkage; Family study; Migraine; Cardiovascular disease; Cerebral disorder; Vascular disease; Pain; Central nervous system disease; X-Chromosome; Cerebrovascular disease
• ISSN: 0340-6717; 1432-1203
• DOI: 10.1007/s004390000329

In a previous study we found evidence for an X-linked genetic component for familial typical migraine in two large Australian white pedigrees, designated MF7 and MF14. Significant excess allele sharing was indicated by nonparametric linkage (NPL) analysis using GENEHUNTER (P=0.031 and P=0.012, respectively), with a combined analysis of the two pedigrees showing further increased evidence for linkage, producing a maximum NPL score of 2.87 (P=0.011 ) at DXS 1123 on Xq27. The present study was aimed at refining the localization of the migraine X-chromosomal component by typing additional markers, performing haplotype analysis and applying a more powerful technique in the analysis of linkage data from these two pedigrees. Results from the haplotype analyses, coupled with linkage analyses that produced a peak GENEHUNTER-PLUS LOD* score of 2.388 (P=0.0005), provide compelling evidence for the presence of a migraine susceptibility locus on chromosome Xq24-28.