Parameter selection of pocket extraction algorithm using interaction interface

• Published in: Journal of Zhejiang University. A. Science Vol. 7; no. 9; pp. 1492 - 1499
• Main Authors: Kim, Chong-Min, Won, Chung-In, Ryu, Joonghyun, Cho, Cheol-Hyung, Bhak, Jonghwa, Kim, Deok-Soo
• Format: Journal Article
• Language: English
• Published: Department of Industrial Engineering, Hanyang University, Seoul 133- 791, Korea%Voronoi Diagram Research Center, Hanyang University, Seoul 133-791, Korea%Samsung Electronics, Suwon, Gyeonggi-do 443-742, Korea%Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea 01.09.2006
• Subjects: 交互作用; 参数选择; 沃罗诺框图; 蛋白质; Pocket; Interaction interface; Voronoi diagram; Protein interaction; Protein
• ISSN: 1673-565X; 1862-1775
• DOI: 10.1631/jzus.2006.A1492

Pockets in proteins have been known to be very important for the life process. There have been several studies in the past to automatically extract the pockets from the structure information of known proteins. However, it is difficult to find a study comparing the precision of the extracted pockets from known pockets on the protein. In this paper, we propose an algorithm for extracting pockets from structure data of proteins and analyze the quality of the algorithm by comparing the extracted pockets with some known pockets. These results in this paper can be used to set the parameter values of the pocket extraction algorithm for getting better results.