Evaluation of the serum level of CTRP-3 and CTRP-6 in patients with Hashimoto's disease and correlation with thyroid hormones and lipid profile

• Published in: Journal of basic and clinical physiology and pharmacology Vol. 36; no. 1; pp. 61 - 67
• Main Authors: Al-Abboody, Rafal Sameer, Heydari, Nadia, Saravani, Mohsen, Nosaratzehi, Shahin, Akbari, Hamideh, Jafari, Seyyed Mehdi
• Format: Journal Article
• Language: English
• Published: Germany Walter de Gruyter GmbH 01.01.2025
• Subjects: Adipokines - blood; Adult; Case-Control Studies; Collagen; Enzymes; Female; Hashimoto Disease - blood; Humans; Lipids - blood; Male; Middle Aged; Pathogenesis; Thyroid gland; Thyroid Hormones - blood; Thyrotropin - blood; Tumor Necrosis Factors - blood; CTRP6; autoimmune diseases; lipid profiles; Hashimoto’s disease; CTRP3; thyroid hormone
• ISSN: 0792-6855; 2191-0286
• DOI: 10.1515/jbcpp-2024-0060

Numerous studies show that the adipokines play a role in on the thyroid axis. The aim of this study was the evaluation of serum level of CTRP-3 and CTRP-6 as a member of the adipokines family in patients with Hashimoto's. The levels of CTRP-3 and CTRP-6 were evaluated with enzyme-linked immunosorbent assay in 70 subjects (35 newly diagnosed Hashimoto's thyroiditis and 35 healthy subjects). Their relationship with the thyroid hormone and some biochemical factors was analyzed. The levels of CTRP3 and CTRP6 in patients with Hashimoto's disease were higher than those in the control group (p<0.05). There was a significant positive correlation between CTRP3 and TSH levels (r=0.286 and p=0.017). There was a significant relationship between CTRP3 and Fasting Blood Sugar (r=0.249 and p=0.038). There was a significant inverse negative correlation between CTRP6 levels and T3 (r=-0.269 and p=0.024), and T4 (r=-0.272 and p=0.023). Moreover, there was a significant positive correlation between CTRP6 serum levels and TSH serum levels (r=0.397 and p=0.001). There was a significant positive correlation between CTRP6 levels and Cholesterol (r=0.351 and p=0.003), and LDL (r=-0.244 and p=0.042). Finally, our results demonstrated that serum levels of CTRP3 and CTRP6 are higher in patients with Hashimoto's compared to the control group and probably play a role in the pathogenesis of Hashimoto's thyroiditis.