Doubling down to make killer T cells

Control of the alternative commitment of immature CD4 + CD8 + T cells to the CD4 + or CD8 + lineage has long been the subject of intense scrutiny. A combination of CITE-seq and functional assays provides significant new insights into the distinct T cell antigen receptor signaling requirements for th...

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Bibliographic Details
Published inNature immunology Vol. 24; no. 9; pp. 1407 - 1408
Main Authors Kappes, Dietmar, Wiest, David L.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.09.2023
Nature Publishing Group
Subjects
631/250/1619/554
631/250/232/2058
631/250/2502
Antigens
Auditions
Biomedical and Life Sciences
Biomedicine
CD4 antigen
CD8 antigen
Cells
Genes
Immunology
Infectious Diseases
Lymphocytes
Lymphocytes T
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news-and-views
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ISSN1529-2908
1529-2916
1529-2916
DOI10.1038/s41590-023-01593-z

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Summary:Control of the alternative commitment of immature CD4 + CD8 + T cells to the CD4 + or CD8 + lineage has long been the subject of intense scrutiny. A combination of CITE-seq and functional assays provides significant new insights into the distinct T cell antigen receptor signaling requirements for these lineage fates.
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-023-01593-z