PREOPERATIVE DIAGNOSIS OF PARATHYROID CARCINOMA

Parathyroid carcinoma is a rare entity in parathyroid neoplasms that cause primary hyperthyroidism (PHPT) and is often difficult to diagnose preoperatively. We studyied clinical features of 6 patients with parathyroid carcinoma (2.6%) from among 235 patients with PHPT undergoing surgery in the last...

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Published inNihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 65; no. 8; pp. 2033 - 2036
Main Authors HAMA, Yoshihisa, KANAI, Toshiharu, MOCHIZUKI, Yasuhiro, KOYAMA, Hiroshi, SHINGU, Kiyoshi, ITO, Kenichi, KOBAYASHI, Shinya, FUJIMORI, Minoru
Format Journal Article
LanguageEnglish
Published Japan Surgical Association 2004
Online AccessGet full text
ISSN1345-2843
1882-5133
1882-5133
DOI10.3919/jjsa.65.2033

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Abstract Parathyroid carcinoma is a rare entity in parathyroid neoplasms that cause primary hyperthyroidism (PHPT) and is often difficult to diagnose preoperatively. We studyied clinical features of 6 patients with parathyroid carcinoma (2.6%) from among 235 patients with PHPT undergoing surgery in the last 36 years. Compared to cases of parathyroid adenoma, findings in parathyroid carcinoma of palpable neck mass (p<0.0001 vs. adenoma), a larger mass (p<0.0001), bone disorders (p=0.04), and higher levels of calcium (p=0.0002) and parathormone (p=0.0005) were significant for diagnosis. PHPT meeting these clinical features turned out to be malignant and are important in determining surgical procedures.
AbstractList Parathyroid carcinoma is a rare entity in parathyroid neoplasms that cause primary hyperthyroidism (PHPT) and is often difficult to diagnose preoperatively. We studyied clinical features of 6 patients with parathyroid carcinoma (2.6%) from among 235 patients with PHPT undergoing surgery in the last 36 years. Compared to cases of parathyroid adenoma, findings in parathyroid carcinoma of palpable neck mass (p<0.0001 vs. adenoma), a larger mass (p<0.0001), bone disorders (p=0.04), and higher levels of calcium (p=0.0002) and parathormone (p=0.0005) were significant for diagnosis. PHPT meeting these clinical features turned out to be malignant and are important in determining surgical procedures.
Author SHINGU, Kiyoshi
KOYAMA, Hiroshi
KANAI, Toshiharu
KOBAYASHI, Shinya
ITO, Kenichi
FUJIMORI, Minoru
MOCHIZUKI, Yasuhiro
HAMA, Yoshihisa
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References 10) Jackson CE, Norum RA, Boyd SB, et al: Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndrome. Surgery 108: 1006-1012, 1990
6) Kebebew E: Parathyroid carcinoma. Curr Treat Options Oncol 2: 347-354, 2001
1) Shane E, Bilezikian JP: Parathyroid carcinoma. a review of 62 patients. Endocrine Rev 3: 218-226, 1982
4) Hundahl SA, Fleming ID, Fremgen AM, et al: Two hundred eighty-six cases of parathyroid carcinoma treated in the U. S. between 1985-1995. A National Cancer Data Base report. Cancer 86: 538-544, 1999
8) 岡本高宏,小原孝男,藤本吉秀他:上皮小体癌の術前診断:術前情報の量的評価.内分泌外科 8: 401-405, 1991
12) Castleman B, Roth SI: Tumors of the parathyroid glands. Armed Forces Institute of Pathology, Washington, 1978, p74
2) Cohn K, Silverman M, Corrado J, et al: Parathyroid carcinoma: The Lahey Clinic experience. Surgery 98: 1095-1110, 1985
3) Obara T, Okamoto T, Kanbe M, et al: Functioning parathyroid carcinoma: clinicopathologic features and rational treatment. Semin Surg Oncol 13: 134-141, 1997
7) Snell SB, Gaar EE, Stevens SP, et al: Parathyroid cancer, a continued diagnostic and therapeutic dilemma: Report of four cases and review of the literature. Am Surg 69: 711-716, 2003
9) Kebebew E, Arici C, Duh QY, et al: Localization and reoperation results for persistent and recurrent parathyroid caarcinoma. Arch Surg 136: 878-885, 2001
11) Hara H, Igarashi A, Yano Y, et al: Ultrasonographic features of parathyroid carcinoma. Endocr J 48: 213-217, 2001
5) Dotzenrath C, Goretzki PE, Sarbia M, et al: Parathyroid carcinoma: problems in diagnosis and the need for radical surgery even in recurrent disease. Eur J Surg Oncol 27: 383-389, 2001
References_xml – reference: 8) 岡本高宏,小原孝男,藤本吉秀他:上皮小体癌の術前診断:術前情報の量的評価.内分泌外科 8: 401-405, 1991
– reference: 11) Hara H, Igarashi A, Yano Y, et al: Ultrasonographic features of parathyroid carcinoma. Endocr J 48: 213-217, 2001
– reference: 2) Cohn K, Silverman M, Corrado J, et al: Parathyroid carcinoma: The Lahey Clinic experience. Surgery 98: 1095-1110, 1985
– reference: 1) Shane E, Bilezikian JP: Parathyroid carcinoma. a review of 62 patients. Endocrine Rev 3: 218-226, 1982
– reference: 12) Castleman B, Roth SI: Tumors of the parathyroid glands. Armed Forces Institute of Pathology, Washington, 1978, p74
– reference: 5) Dotzenrath C, Goretzki PE, Sarbia M, et al: Parathyroid carcinoma: problems in diagnosis and the need for radical surgery even in recurrent disease. Eur J Surg Oncol 27: 383-389, 2001
– reference: 3) Obara T, Okamoto T, Kanbe M, et al: Functioning parathyroid carcinoma: clinicopathologic features and rational treatment. Semin Surg Oncol 13: 134-141, 1997
– reference: 6) Kebebew E: Parathyroid carcinoma. Curr Treat Options Oncol 2: 347-354, 2001
– reference: 10) Jackson CE, Norum RA, Boyd SB, et al: Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndrome. Surgery 108: 1006-1012, 1990
– reference: 7) Snell SB, Gaar EE, Stevens SP, et al: Parathyroid cancer, a continued diagnostic and therapeutic dilemma: Report of four cases and review of the literature. Am Surg 69: 711-716, 2003
– reference: 4) Hundahl SA, Fleming ID, Fremgen AM, et al: Two hundred eighty-six cases of parathyroid carcinoma treated in the U. S. between 1985-1995. A National Cancer Data Base report. Cancer 86: 538-544, 1999
– reference: 9) Kebebew E, Arici C, Duh QY, et al: Localization and reoperation results for persistent and recurrent parathyroid caarcinoma. Arch Surg 136: 878-885, 2001
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