PREOPERATIVE DIAGNOSIS OF PARATHYROID CARCINOMA

Parathyroid carcinoma is a rare entity in parathyroid neoplasms that cause primary hyperthyroidism (PHPT) and is often difficult to diagnose preoperatively. We studyied clinical features of 6 patients with parathyroid carcinoma (2.6%) from among 235 patients with PHPT undergoing surgery in the last...

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Published inNihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 65; no. 8; pp. 2033 - 2036
Main Authors HAMA, Yoshihisa, KANAI, Toshiharu, MOCHIZUKI, Yasuhiro, KOYAMA, Hiroshi, SHINGU, Kiyoshi, ITO, Kenichi, KOBAYASHI, Shinya, FUJIMORI, Minoru
Format Journal Article
LanguageEnglish
Published Japan Surgical Association 2004
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ISSN1345-2843
1882-5133
1882-5133
DOI10.3919/jjsa.65.2033

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Summary:Parathyroid carcinoma is a rare entity in parathyroid neoplasms that cause primary hyperthyroidism (PHPT) and is often difficult to diagnose preoperatively. We studyied clinical features of 6 patients with parathyroid carcinoma (2.6%) from among 235 patients with PHPT undergoing surgery in the last 36 years. Compared to cases of parathyroid adenoma, findings in parathyroid carcinoma of palpable neck mass (p<0.0001 vs. adenoma), a larger mass (p<0.0001), bone disorders (p=0.04), and higher levels of calcium (p=0.0002) and parathormone (p=0.0005) were significant for diagnosis. PHPT meeting these clinical features turned out to be malignant and are important in determining surgical procedures.
ISSN:1345-2843
1882-5133
1882-5133
DOI:10.3919/jjsa.65.2033